Publications by authors named "Madeline Wessels"
Article Synopsis
- - The study aimed to analyze whether there’s a connection between adverse event (AE) attribution and treatment allocation in cystic fibrosis clinical trials, emphasizing a need to assess how accurately trial investigators link AEs to study drugs.
- - A secondary analysis of data from four CF trials included 785 subjects who reported nearly 12,000 AEs, finding that while there was a trend of higher AE attribution to the active drug compared to placebo, the results were not statistically significant.
- - Notably, the study found that female participants were less likely to have AEs attributed to the study drug, pointing to the need for more research on this demographic and improvements in clinical trial monitoring practices.
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- Categorizing late-onset Alzheimer's patients into biologically coherent subgroups enhances the potential for personalized medicine.
- The study evaluated data from five different studies, involving over 4,000 participants, to analyze cognitive performance and genetic factors related to Alzheimer’s.
- Findings indicated that individuals with significant memory impairment were more likely to carry the APOE ε4 allele, along with the identification of 33 new genetic loci that could be related to Alzheimer’s across the groups tested.*