Publications by authors named "Madeline R McCrea"
Advances in molecular therapies for targeting pathophysiology in spinal cord injury.
Expert Opin Ther Targets
March 2023
Article Synopsis
- Spinal cord injury (SCI) affects 25,000-50,000 individuals globally annually, leading to significant damage that is worsened by secondary injuries like inflammation and cell death, with no current cure available.
- Researchers are exploring various therapeutic methods to repair spinal cord damage, including neuroprotective agents, gene targeting for axon regeneration, and improving neural repair through epigenetic factors and enhancing neuronal connections.
- While there have been promising advancements in preclinical therapies for SCI, challenges remain in creating effective treatments, boosting neuronal regeneration, and translating successful strategies to human patients.