Publications by authors named "Madeline McKean"
Front Neurosci
March 2023
Article Synopsis
- The generation of neurons in the central nervous system involves radial glia, which are mitotic progenitors that rapidly proliferate to form a dense neurepithelium and produce different neuronal sub-types.
- Molecular mechanisms behind this process are not well understood, but a family of enzymes called GDE proteins, including GDE6, play a role in neural development.
- Research shows that overexpression of GDE6 leads to neural tube hyperplasia, abnormal neurepithelium growth, and a decrease in the production of motor neurons, indicating its important role in regulating radial glia and neurogenesis alongside GDE2.
