A Rare Report of Proliferative Fasciitis of the Ear in a Pediatric Patient.

Nodular fasciitis is a relatively uncommon disorder that occurs in soft tissues and results in a rapidly growing mass predominately found in adults. Proliferative fasciitis is a rarer variant of nodular fasciitis that is typically found in adults over age 40 and is extremely rare in pediatric patients. This case report involves a pediatric patient who presented with a large, posterior, rapidly growing mass on the right ear.

An introduction to the Cornell Note system.

Objective: The success of note writing has been a topic of research dating back to the days of Plato. Students now have access to complete libraries of books and notes on computers, tablets, and even phones. Modern note-taking methods use premade handouts, "Chalk Talk" lectures with faculty, and prescribed note-taking strategies.

Deregulation of a Network of mRNA and miRNA Genes Reveals That CK2 and MEK Inhibitors May Synergize to Induce Apoptosis KRAS-Active NSCLC.

KRAS-activation mutations occur in 25% to 40% of lung adenocarcinomas and are a known mechanism of epidermal growth factor receptor inhibitor (EGFRI) resistance. There are currently no targeted therapies approved specifically for the treatment of KRAS-active non-small cell lung cancers (NSCLC). Attempts to target mutant KRAS have failed in clinical studies leaving no targeted therapy option for these patients.

cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy.

Malignant melanoma of the skin is the leading cause of death from skin cancer and ranks fifth in cancer incidence among all cancers in the United States. While melanoma mortality has remained steady for the past several decades, melanoma incidence has been increasing, particularly among fair-skinned individuals. According to the American Cancer Society, nearly 10,000 people in the United States will die from melanoma this year.

A microRNA signature of response to erlotinib is descriptive of TGFβ behaviour in NSCLC.

Our previous work identified a 13-gene miRNA signature predictive of response to the epidermal growth factor receptor (EGFR) inhibitor, erlotinib, in Non-Small Cell Lung Cancer cell lines. Bioinformatic analysis of the signature showed a functional convergence on TGFβ canonical signalling. We hypothesized that TGFβ signalling controls expression of the miRNA genes comprising an erlotinib response signature in NSCLC.