Publications by authors named "Madeline Hartnoll"
Article Synopsis
- SARS-CoV-2 variant JN.1, featuring a mutation L455S, has surpassed earlier variants, becoming the dominant strain due to its higher infectivity compared to BA.2.86.
- The increased infectivity of JN.1 is linked to improved entry efficiency and spike protein cleavage, aided by the L455S mutation altering how the spike protein binds to ACE2 receptors.
- Research also evaluates the distinct virological traits between JN.1 and other Omicron sublineages, enhancing our understanding of their transmissibility and immune response behaviors.
Background: Earlier Omicron subvariants including BA.1, BA.2, and BA.
View Article and Find Full Text PDFThe Enterovirus (EV) genus includes several important human and animal pathogens. EV-A71, EV-D68, poliovirus (PV), and coxsackievirus (CV) outbreaks have affected millions worldwide, causing a range of upper respiratory, skin, and neuromuscular diseases, including acute flaccid myelitis, and hand-foot-and-mouth disease. There are no FDA-approved antiviral therapeutics for these enteroviruses.
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