Trajectories and revolutions in popular melody based on U.S. charts from 1950 to 2023.

In the past century, the history of popular music has been analyzed from many different perspectives, with sociologists, musicologists and philosophers all offering distinct narratives characterizing the evolution of popular music. However, quantitative studies on this subject began only in the last decade and focused on features extracted from raw audio, which limits the scope to low-level components of music. The present study investigates the evolution of a more abstract dimension of popular music, specifically melody, using a new dataset of popular melodies spanning from 1950 to 2023.

Early Detection of Apathetic Phenotypes in Huntington's Disease Knock-in Mice Using Open Source Tools.

Apathy is one of the most prevalent and progressive psychiatric symptoms in Huntington's disease (HD) patients. However, preclinical work in HD mouse models tends to focus on molecular and motor, rather than affective, phenotypes. Measuring behavior in mice often produces noisy data and requires large cohorts to detect phenotypic rescue with appropriate power.