Publications by authors named "Madeline Gilstrap"
Exp Biol Med (Maywood)
August 2018
Article Synopsis
- Recent studies indicate that measuring fecal mRNA transcripts can be a less invasive alternative to the lactulose:mannitol test for assessing environmental enteric dysfunction in rural African children, particularly infants.
- The study evaluated seven specific fecal host transcripts (CD53, CDX1, HLA-DRA, TNF, S100A8, MUC12, REG1A) and found that none were effective in predicting severe environmental enteric dysfunction, with only CDX1 and REG1A showing some correlation to gut permeability.
- The prevalence of severe environmental enteric dysfunction in infants was found to be 14%, which is significantly lower than previously reported rates in older children, suggesting variations in vulnerability and possibly different underlying factors affecting gut health
