Publications by authors named "Madeline Ganshert"
Article Synopsis
- Advancements in 3D cell culture techniques allow for the creation of patient-derived models that replicate the native tumor environment, making them more relevant for studying diseases like cancer compared to traditional 2D models.
- Patient-derived organoids (PDOs) and patient-derived xenograft organoids (PDXOs) are highlighted as key tools for understanding triple-negative breast cancer (TNBC), a challenging type of cancer due to its aggressive nature and limited treatment options.
- The review discusses the importance of various 3D cancer models and methodologies, including live-cell imaging and innovative culturing systems, to enhance research and therapeutic strategies in cancer treatment.
G-protein-coupled receptors (GPCRs) contribute to numerous physiological processes via complex network mechanisms. While indirect signaling assays (Ca mobilization, cAMP production, and GTPS binding) have been useful in identifying and characterizing downstream signaling mechanisms of GPCRs, these methods lack measurements of direct binding affinities, kinetics, binding specificity, and selectivity that are important parameters in GPCR drug discovery. In comparison to existing direct methods that use radio- or fluorescent labels, label-free techniques can closely emulate the native interactions around binding partners.
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