Publications by authors named "Madeline Behee"
Article Synopsis
- Chronic alcohol consumption negatively affects lung immunity, making individuals with alcohol use disorder more prone to serious inflammatory lung conditions.
- Research using human lung transcriptomics and mouse models indicates that males experience greater disruption of lung immunity due to alcohol than females.
- The study highlights that alcohol significantly downregulates immune-related genes in the lungs, suggesting immunometabolic changes and reduced mTOR signaling play a key role in this immune dysregulation.
The inhibition of soluble epoxide hydrolase (sEH) can reduce the level of dihydroxyeicosatrienoic acids (DHETs) effectively maintaining endogenous epoxyeicosatrienoic acids (EETs) levels, resulting in the amelioration of inflammation and pain. Consequently, the development of sEH inhibitors has been a prominent research area for over two decades. In the present study, we synthesized and evaluated sulfonyl urea derivatives for their potential to inhibit sEH.
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- Pulmonary fibrosis (PF) is a complex disease with limited treatment options and poor outcomes, highlighting the need for new therapies.
- This study investigates changes in lung function, gene expression, and metabolic profiles in mice over time after receiving bleomycin, revealing important gene networks linked to disease progression.
- The research proposes a multi-omics approach to connect mouse models of PF with human cases, suggesting cannabinoid receptor 1 (CBR) antagonism as a potential therapeutic target for clinical applications.
Resolvin E1 (RvE1), a specialized pro-resolving mediator (SPM), improves glucose homeostasis in inbred mouse models of obesity. However, an impediment toward translation is that obesity is a highly heterogenous disease in which individuals will respond very differently to interventions such as RvE1. Thus, there is a need to study SPMs in the context of modeling the heterogeneity of obesity that is observed in humans.
View Article and Find Full Text PDFBackground: Specialized pro-resolving mediators (SPMs), synthesized from PUFAs, resolve inflammation and return damaged tissue to homeostasis. Thus, increasing metabolites of the SPM biosynthetic pathway may have potential health benefits for select clinical populations, such as subjects with obesity who display dysregulation of SPM metabolism. However, the concentrations of SPMs and their metabolic intermediates in humans with obesity remains unclear.
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