Publications by authors named "Madeline Bailey"
Despite the widespread popularity of the "scratch assay," where a pipette is dragged manually through cultured tissue to create a gap to study cell migration and healing, it carries significant drawbacks. Its heavy reliance on manual technique can complicate quantification, reduce throughput, and limit the versatility and reproducibility. We present an open-source, low-cost, accessible, robotic scratching platform that addresses all of the core issues.
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- The text discusses the traditional "scratch assay," a method used to study cell migration and healing by creating injury gaps in cultured tissue, highlighting the challenges of manual techniques that affect reproducibility and efficiency.
- It introduces a new open-source, low-cost robotic scratching platform that overcomes these limitations, allowing for precise and reproducible scratches in various tissue types while maintaining high throughput.
- The robotic system also offers innovative features like sculpting specific tissue shapes and facilitating complex co-culture experiments, enhancing its utility for advanced tissue engineering and cell research.