Publications by authors named "Madeleine Wetzel"
Commun Med (Lond)
October 2024
Article Synopsis
- * A study of 445 PD patients revealed a higher diversity of microbes compared to 221 controls, with specific bacterial overabundances and depletions identified as key signatures of PD.
- * Findings indicate that certain oral microbiome characteristics could act as potential biomarkers for early PD detection, particularly in relation to non-motor symptoms linked to the peripheral nervous system.
Article Synopsis
- The LRRK2 G2019S variant is the leading cause of hereditary Parkinson's disease, studied in a large cohort of carriers and controls over 3.5 years, revealing significant insights into disease progression and symptoms.
- G2019S carriers face a 49% chance of developing PD by age 80, with a 10-fold increased risk compared to non-carriers, and an even higher risk for those with elevated polygenic risk scores.
- The research highlights that G2019S-associated PD is a slower-progressing form, primarily affecting motor functions while showing fewer non-motor symptoms, suggesting a need to adjust current diagnostic criteria for earlier detection.
