Publications by authors named "Madeleine Polet"
Because of their antimicrobial properties, silver nanoparticles are increasingly incorporated in food-related and hygiene products, which thereby could lead to their ingestion. Although their cytotoxicity mediated by oxidative stress has been largely studied, their effects on inflammation remain controversial. Moreover, the involvement of silver ions (originating from Ag0 oxidation) in their mode of action is still unclear.
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- Consumption of ethanol can cause severe inflammation and toxicity in human organs, prompting this study to explore the protective effects of extracts from Rhus tripartita (sumac) leaves, root, and stem on intestinal cells.
- Results indicated that ethanol induced cytotoxicity, but co-administering the sumac extracts partially alleviated this effect.
- Chemical analyses using NMR and mass spectrometry showed notable differences in the compositions of the three plant extracts, which may explain their varying protective effects against ethanol-induced inflammation.
Interaction of nanoparticles with food matrix components may cause unpredictable health complications. Using an improved Caco-2 cell-based in vitro (co-)culture model the potential of quercetin as one of the major food flavonoids to alter the effect of silver nanoparticles (Ag-NPs) <20 nm in the human intestinal mucosa at real life concentrations was investigated. Ag-NPs (15-90 μg/ml) decreased cell viability and reduced thiol groups, induced oxidative/nitrosative stress and lipid peroxidation and led to activity changes of various antioxidant enzymes after 3h exposure.
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