Publications by authors named "Madeleine McCallum"
Mol Psychiatry
August 2023
Article Synopsis
- Bipolar disorder is characterized by severe mood swings and can disrupt thinking and behavior, with various inherited and environmental factors contributing to its complexity.
- The text reviews the underlying molecular mechanisms of bipolar depression, such as mitochondrial dysfunction, inflammation, and oxidative stress, and discusses the potential of trimetazidine as a treatment.
- Trimetazidine, initially used for angina pectoris, shows promise due to its anti-inflammatory and antioxidant effects, as well as its ability to normalize mitochondrial function, warranting further clinical trials for treating bipolar depression.
