Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.

Background: Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.

Methods: Using electronic health records, 380 participants with MS were identified.

Mapping the relationship of white matter lesions to depression in multiple sclerosis.

Importance: Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects nearly one million people in the United States. Up to 50% of patients with MS experience depression.

Objective: To investigate how white matter network disruption is related to depression in MS.