Publications by authors named "Madeleine Fandrich"
Purpose: Human OX40 (hOX40/CD134), a member of the TNF receptor superfamily, is mainly expressed on activated T lymphocytes. Triggered by its ligand OX40L (CD252), it provides costimulatory signals that support the differentiation, proliferation and long-term survival of T cells. Besides being a relevant therapeutic target, hOX40 is also an important biomarker for monitoring the presence or infiltration of activated T cells within the tumor microenvironment (TME), the inflammatory microenvironment (IME) in immune-mediated diseases (IMIDs) and the lymphatic organs.
View Article and Find Full Text PDFBackground: Prior investigations have elucidated pathophysiological interactions involving blood coagulation and neurodegenerative diseases. These interactions pertain to age-related effects and a mild platelet antiaggregant function of exogenous α-Synuclein.
Objective: Our study sought to explore whether cerebrospinal fluid (CSF) levels of tissue factor (TF), the initiator of the extrinsic pathway of hemostasis, differ between controls (CON) compared to patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB), considering that these conditions represent a spectrum of α-Synuclein pathology.
Background And Purpose: Parkinson's disease (PD) is an age-related condition characterized by substantial phenotypic variability. Consequently, pathways and proteins involved in biological aging, such as the central aging pathway comprising insulin-like growth factor 1-α-Klotho-sirtuin 1-forkhead box O3-peroxisome proliferator-activated receptor γ, may potentially influence disease progression.
Methods: Cerebrospinal fluid (CSF) levels of α-Klotho in 471 PD patients were examined.
Article Synopsis
- Researchers created an RSV multiplex immunoassay to measure antibody levels against different RSV proteins, which could help understand immune protection for vaccines and therapies.
- The assay was rigorously tested and shown to effectively identify RSV infection subtypes in a significant portion of samples from children under 2 and in various populations.
- The immunoassay demonstrates strong performance and scalability, making it a valuable tool for future studies on RSV immunity and population health.