Publications by authors named "Madeleine E Garcia"
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et al., 2016, Acta Neuropathologica, 131, 75-86).
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- Gigantopyramidal neurons, also known as Betz cells, are large neurons with extensive dendrites found in the primary motor cortex of mammals, and their morphology has been studied across various species.
- This study utilized qualitative and quantitative methods to analyze the structure of these neurons in 19 different mammalian species, highlighting significant differences in dendritic shapes and sizes between species, especially in feliforms like lions and tigers.
- The results showed that gigantopyramidal neurons have larger dendritic measures compared to other pyramidal neurons and that these differences can help differentiate taxonomic groups based on their somatodendritic morphology.
Despite extensive investigations of the neocortex in the domestic cat, little is known about neuronal morphology in larger felids. To this end, the present study characterized and quantified the somatodendritic morphology of neocortical neurons in prefrontal, motor, and visual cortices of the Siberian tiger (Panthera tigris altaica) and clouded leopard (Neofelis nebulosa). After neurons were stained with a modified Golgi technique (N = 194), dendritic branching and spine distributions were analyzed using computer-assisted morphometry.
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