Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation.

As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a-l) were efficiently synthesized in excellent yields by the popular 'Fisher-Indole synthesis' approach. The structure elucidation of the target compounds was carried out by different spectral techniques including H-NMR, C-NMR, ESI Mass, and FTIR analysis. Additionally, the proposed structure of 7i was proved by single-crystal X-ray analysis.

Facile synthesis, characterization and enhanced catalytic reduction of 4-nitrophenol using NaBH by undoped and Sm, Gd, Hf doped LaO nanoparticles.

This work focuses on the synthesis of undoped and doped lanthanum oxide nanoparticles (LaO NPs) by a simple co-precipitation method for the catalytic reduction of 4-nitrophenol (4-NP) using NaBH as a reducing agent. Their optical properties, morphologies, structure, chemical compositions and electronic properties were carefully characterized by XRD, FTIR, SEM, TEM, PL and UV-visible absorption spectroscopy. The SEM and TEM images showed various shape morphologies and sizes of the particles.

1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation.

A facile and convenient approach has been designed for the synthesis of novel prototypes that possess the advantage of the two pharmacophores of chromene and 1,2,3-triazole in a single molecular backbone, were evaluated against H37Rv strain. The new analogues 1,2,3-triazole-fused spirochromenes were accomplished in four step synthetic strategy utilizing click chemistry ([3 + 2] Huisgen cycloaddition) in the ultimate step. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 7a.