Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology.

Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular imaging, IVUS-NIRF, IVUS intravascular photoacoustic imaging and combined fluorescence lifetime-IVUS imaging.

The vulnerable artery: early and rapid deposition of lipid in coronary arteries is associated with subsequent development of thin-cap fibroatheromas.

Aims: We aimed to determine whether intravascular ultrasound (IVUS) and near infrared spectroscopy (NIRS) could identify arteries which would subsequently develop a thin-cap fibroatheroma (TCFA).

Methods And Results: Three-vessel angiography, IVUS and NIRS evaluations were performed at three, six and nine months after induction of diabetes mellitus and hypercholesterolaemia in 13 Yorkshire pigs (n=37 arteries). In vivo total arterial plaque plus media (P+M) area, echo-attenuated plaque (AP) area by IVUS, and lipid core burden index (LCBI) by NIRS were compared to histology at nine months.

Photothermal Breaking of Emulsions Stabilized with Graphene.

Pristine graphene particles prepared using an aqueous phase exfoliation technique have been used to promote the stabilization of emulsions through adsorption at the oil-water interface. Highly localized phase separation of these ultrastable emulsions could, however, be induced through photothermal heating of the graphene particles at the interface exposed to near-infrared light. The graphene wettability, which is a key determinant in preventing droplet coalescence was altered through the adsorption of nonionic block copolymer surfactants.

Experimental demonstration of linearly polarized 2-10 μm supercontinuum generation in a chalcogenide rib waveguide.

This Letter reports the production of a supercontinuum extending from ≈2  μm to >10  μm generated using a chalcogenide buried rib waveguide pumped with 330 femtosecond pulses at 4.184 μm. This is, to the best of our knowledge, the broadest mid-infrared supercontinuum generated in any planar waveguide platform.

Confirmation of the Intracoronary Near-Infrared Spectroscopy Threshold of Lipid-Rich Plaques That Underlie ST-Segment-Elevation Myocardial Infarction.

Objective: In a previous exploratory analysis, intracoronary near-infrared spectroscopy (NIRS) found the majority of culprit lesions in ST-segment-elevation myocardial infarction (STEMI) to contain a maximum lipid core burden index in 4 mm (maxLCBI4mm) of >400. This initial study was limited by a small sample size, enrollment at a single center, and post hoc selection of the maxLCBI4mm ≥400 threshold. This study was designed a priori to substantiate the ability of NIRS to discriminate STEMI culprit from nonculprit segments and to confirm the performance of the maxLCBI4mm ≥400 threshold.

Preclinical evaluation of the AR inhibitor enzalutamide in triple-negative breast cancer cells.

The androgen receptor (AR) is present in approximately 80% of invasive breast cancer patients and in up to 30% of patients with triple-negative breast cancer (TNBC). Therefore, our aim was to investigate the targeting of AR as a possible hormonal approach to the treatment of TNBC. Analysis of 2091 patients revealed an association between AR expression and poor overall survival, selectively in patients with the basal subtype of breast cancer, the vast majority of which are TNBC.

Tailoring of the Brillouin gain for on-chip widely tunable and reconfigurable broadband microwave photonic filters.

An unprecedented Brillouin gain of 44 dB in a photonic chip enables the realization of broadly tunable and reconfigurable integrated microwave photonic filters. More than a decade bandwidth reconfigurability from 30 up to 440 MHz, with a passband ripple <1.9  dB is achieved by tailoring the Brillouin pump.

A clinical profile of compulsive exercise in adolescent inpatients with anorexia nervosa.

Background: The aim of the current study was to contribute to the development of a clinical profile of compulsive exercise in adolescents with Anorexia Nervosa (AN), by examining associations between compulsive exercise and eating and general psychopathology.

Method: A sample of 60 female adolescent inpatients with AN completed a self-report measure of compulsive exercise and a series of standardized self-report questionnaires assessing eating and general psychopathology.

Results: Higher levels of compulsive exercise were associated with increased levels of eating disorder psychopathology and anxiety.

Collaborative Data Analytics with DataHub.

While there have been many solutions proposed for storing and analyzing large volumes of data, all of these solutions have limited support for , especially given the many individuals and teams are simultaneously analyzing, modifying and exchanging datasets, employing a number of heterogeneous tools or languages for data analysis, and writing scripts to clean, preprocess, or query data. We demonstrate DataHub, a unified platform with the ability to load, store, query, collaboratively analyze, interactively visualize, interface with external applications, and share datasets. We will demonstrate the following aspects of the DataHub platform: (a) : multiple conference attendees can concurrently update the database and browse the different versions and inspect conflicts; (b) : conference attendees will be able to effortlessly ingest, query, and visualize data using our existing apps; (c) , : conference attendees will be able to analyze datasets in R, Python, and Matlab, while the inputs and the results are still stored in DataHub.

Large lipid-rich coronary plaques detected by near-infrared spectroscopy at non-stented sites in the target artery identify patients likely to experience future major adverse cardiovascular events.

Aims: A recent study demonstrated that intracoronary near-infrared spectroscopy (NIRS) findings in non-target vessels are associated with major adverse cardiovascular and cerebrovascular events (MACCE). It is unknown whether NIRS findings at non-stented sites in target vessels are similarly associated with future MACCE. This study evaluated the association between large lipid-rich plaques (LRP) detected by NIRS at non-stented sites in a target artery and subsequent MACCE.

Rapid Sampling for Visualizations with Ordering Guarantees.

Visualizations are frequently used as a means to understand trends and gather insights from datasets, but often take a long time to generate. In this paper, we focus on the problem of . Our primary focus will be on sampling algorithms that preserve the visual property of ; our techniques will also apply to some other visual properties.

SeeDB: Efficient Data-Driven Visualization Recommendations to Support Visual Analytics.

Data analysts often build visualizations as the first step in their analytical workflow. However, when working with high-dimensional datasets, identifying visualizations that show relevant or desired trends in data can be laborious. We propose SeeDB, a visualization recommendation engine to facilitate fast visual analysis: given a subset of data to be studied, SeeDB intelligently explores the space of visualizations, evaluates promising visualizations for trends, and recommends those it deems most "useful" or "interesting".

Mid-infrared nonlinear optical response of Si-Ge waveguides with ultra-short optical pulses.

We characterize the nonlinear optical response of low loss Si(0.6)Ge(0.4) / Si waveguides in the mid-infrared between 3.

A systematic review of approaches to refeeding in patients with anorexia nervosa.

Objective: Given the importance of weight restoration for recovery in patients with anorexia nervosa (AN), we examined approaches to refeeding in adolescents and adults across treatment settings.

Methods: Systematic review of PubMed, PsycINFO, Scopus, and Clinical Trials databases (1960-2015) using terms refeeding, weight restoration, hypophosphatemia, anorexia nervosa, anorexia, and anorexic.

Results: Of 948 screened abstracts, 27 met these inclusion criteria: participants had AN; reproducible refeeding approach; weight gain, hypophosphatemia or cognitive/behavioral outcomes.

Early weight gain in family-based treatment predicts greater weight gain and remission at the end of treatment and remission at 12-month follow-up in adolescent anorexia nervosa.

Objective: To Identify whether early weight gain in family-based treatment (FBT) predicted greater weight and remission at end of FBT and 12-month follow-up.

Method: Eighty-two adolescents, with anorexia nervosa, participated in a randomized control trial comparing brief hospitalization for medical stabilization and hospitalization for weight restoration to 90% expected body weight (EBW) (1:1), followed by 20 sessions of FBT. Sixty-nine completed trial protocol.

Near-infrared spectroscopy-intravascular ultrasound: scientific basis and clinical applications.

Coronary angiography underestimates the magnitude of the atherosclerotic burden and cannot detect the presence of disease in the early phases. Recognition of these inherent limitations of angiography has been an impetus for the development of other coronary imaging techniques. The novel near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) catheters can detect and quantify the presence of lipid core in the atherosclerotic plaque and associate it with other features such as lumen size and plaque architecture.

High Q factor chalcogenide ring resonators for cavity-enhanced MIR spectroscopic sensing.

We report the characteristics of high Q factor chalcogenide ring resonators designed for sensing in the mid-infrared (MIR). The resonators consisted of an exposed Ge11.5As24Se64.

Near-Infrared Spectroscopy Enhances Intravascular Ultrasound Assessment of Vulnerable Coronary Plaque: A Combined Pathological and In Vivo Study.

Objectives: Pathological studies demonstrate the dual significance of plaque burden (PB) and lipid composition for mediating coronary plaque vulnerability. We evaluated relationships between intravascular ultrasound (IVUS)-derived PB and arterial remodeling with near-infrared spectroscopy (NIRS)-derived lipid content in ex vivo and in vivo human coronary arteries.

Approach And Results: Ex vivo coronary NIRS and IVUS imaging was performed through blood in 116 coronary arteries of 51 autopsied hearts, followed by 2-mm block sectioning (n=2070) and histological grading according to modified American Heart Association criteria.

ADAM10: a new player in breast cancer progression?

Background: The ADAM proteases are best known for their role in shedding the extracellular domain of transmembrane proteins. Among the transmembrane proteins shed by ADAM10 are notch, HER2, E-cadherin, CD44, L1 and the EGFR ligands, EGF and betacellulin. As cleavage of several of these proteins has been implicated in cancer formation and progression, we hypothesised that ADAM10 is also involved in these processes.

Observation of Photon Echoes From Evanescently Coupled Rare-Earth Ions in a Planar Waveguide.

We report the measurement of the inhomogeneous linewidth, homogeneous linewidth, and spin-state lifetime of Pr3+ ions in a novel waveguide architecture. The TeO2 slab waveguide deposited on a bulk Pr3+∶Y2SiO5 crystal allows the 3H4↔1D2 transition of Pr3+ ions to be probed by the optical evanescent field that extends into the substrate. The 2-GHz inhomogeneous linewidth, the optical coherence time of 70±5  μs, and the spin-state lifetime of 9.

Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.

The majority of women diagnosed with lymph node-negative breast cancer are unnecessarily treated with damaging chemotherapeutics after surgical resection. This highlights the importance of understanding and more accurately predicting patient prognosis. In the present study, we define the transcriptional networks regulating well-established prognostic gene expression signatures.

Plaque Characterization to Inform the Prediction and Prevention of Periprocedural Myocardial Infarction During Percutaneous Coronary Intervention: The CANARY Trial (Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow).

Objectives: This study sought to determine whether pre-percutaneous coronary intervention (PCI) plaque characterization using near-infrared spectroscopy identifies lipid-rich plaques at risk of periprocedural myonecrosis and whether these events may be prevented by the use of a distal protection filter during PCI.

Background: Lipid-rich plaques may be prone to distal embolization and periprocedural myocardial infarction (MI) in patients undergoing PCI.

Methods: Patients undergoing stent implantation of a single native coronary lesion were enrolled in a multicenter, prospective trial.

Positive and negative phototunability of chalcogenide (AMTIR-1) microdisk resonator.

We demonstrate externally photo-induced partially-reversible tuning of the resonance of a microdisk made of AMTIR-1 (Ge(33)As(12)Se(55)). We have achieved for the first time, to the best of our knowledge, both positive and negative shift in a microresonator with external tuning. A positive resonance shift of 1 nm and a negative resonance shift of 0.

Nonlinear optical response of low loss silicon germanium waveguides in the mid-infrared.

We have investigated the nonlinear optical response of low loss Si(0.6)Ge(0.4) / Si waveguides in the mid-infrared wavelength range from 3.