Crystal structure and Hirshfeld surface analysis of -2-[2-(4-chloro-phen-yl)-3,4-di-hydro-2-1-benzo-pyran-4-yl-idene]hydrazine-1-carbo-thio-amide.

In the title compound, CHNOSCl, a Schiff base derivative of a thio-semicarbazide with a flavanone, the 4-chlorophenyl ring is inclined to the benzene ring of the chromane ring system by 30.72 (12)°. The pyran ring has an envelope conformation with the methine C atom as the flap.

Mycobacterium tuberculosis chorismate mutase: A potential target for TB.

Mycobacterium tuberculosis chorismate mutase (MtbCM) catalyzes the rearrangement of chorismate to prephenate in the shikimate biosynthetic pathway to form the essential amino acids, phenylalanine and tyrosine. Two genes encoding chorismate mutase have been identified in Mtb. The secretory form,∗MtbCM (encoded by Rv1885c) is assumed to play a key role in pathogenesis of tuberculosis.

HIV-1 associated Topoisomerase IIβ kinase: a potential pharmacological target for viral replication.

Viruses have been found to exhibit protein kinase activity associated with their purified viral particles. HIV-1 virus particles possess a novel 72 kD protein, Topoisomerase II beta kinase (Topo IIβKHIV) activity. The enzyme, isolated and purified from PEGprecipitated HIV-1 particles, is insensitive against a diverse set of known kinase inhibitors.

Ethyl 4-(2-fur-yl)-2-oxochroman-3-carboxyl-ate.

The title compound, C(16)H(14)O(5), was prepared from the reaction of 3-carbethoxy-coumarin with furan in the presence of AlCl(3) as catalyst. In the crystal, inter-molecular C-H⋯O hydrogen-bonding inter-actions between four mol-ecules lead to a tetra-mer in the unit cell. The furan ring is anti-periplanar [C-C-C-O = 167.

Self-assembly of a fluorescent chiral zinc(II) complex that leads to supramolecular helices.

The chiral Zn(II) complex [ZnLCl(2)], 1 {L = 4-methyl-2,6-di[(S)-(+)-1-phenylethyliminomethyl] phenol}, self-assembles via C-H...