Prolonged-release minitablets with carbamazepine - preliminary observations in vitro.

Objective: The aim was to develop prolonged-release minitablets (MT) with carbamazepine (CBZ).

Methods: Matrix-type 3-mm MT (5 mg CBZ) were prepared by direct compression using hydrophilic (hypromellose) or hydrophobic polymers (ethylcellulose, Kollidon SR, glyceryl behenate). Coated prolonged-release MT (2.