Publications by authors named "Madalyn Hague"
Am J Transl Res
July 2023
Article Synopsis
- The study aimed to create an animal model that distinguishes between joint instability and inflammation's effects on posttraumatic osteoarthritis (PTOA), proposing that their modified drilling procedure would induce cartilage damage and inflammation without altering gait.
- Twenty-four Yucatan minipigs were divided into two groups, one undergoing the modified intra-articular drilling (mIAD) and the other serving as a sham control, with outcomes assessed through various evaluations 15 weeks post-surgery.
- Results showed that mIAD knees had significantly more cartilage damage and inflammation markers than controls, but no notable changes in gait mechanics, suggesting this model is useful for studying inflammatory roles in PTOA and developing relevant therapies.
Bioengineering (Basel)
July 2023
Article Synopsis
- - The study investigates how neuromuscular function could influence the risk of posttraumatic osteoarthritis (PTOA) in patients who have undergone anterior cruciate ligament (ACL) reconstruction, highlighting the need for effective analysis tools.
- - Researchers compared the muscle activity patterns of ACL-reconstructed patients to healthy controls using EMG recording during a hop activity, finding that the muscle activation strategies of ACLR patients were globally adapted and symmetrical but differed significantly from those of healthy individuals.
- - The results indicated that smaller thigh muscle girth in the affected leg was the strongest predictor of worse MRI outcomes related to osteoarthritis, suggesting a potential link between muscle activation patterns and PTOA risk that warrants further investigation.
