Promoting Excellence in Symptom Management Case Series: Case Study: A New Intervention for Rapid End-of-Life Symptom Control in the Home Setting.

The oral route is compromised for nearly all patients at the end of life (EOL). This article reviews the benefits and burdens of the usual alternative routes of medication delivery when the oral route fails and presents a case study on the use of a new innovation for the rectal delivery of medication to control EOL symptoms. A 62-year-old male hospice patient with end-stage metastatic prostate cancer presented with severe symptoms (Face, Legs, Activity, Cry and Consolability scale score, 9/10) that were uncontrollable with medications given via oral or sublingual routes.

Pharmacokinetics of Phenobarbital in Microenema Via Macy Catheter Versus Suppository.

Context: The oral route is compromised for nearly all patients approaching death. When agitation, seizures, or other intractable symptoms occur, a quick, discreet, comfortable, and effective alternate route for medication delivery that is easy to administer in the home setting is highly desirable.

Objectives: To characterize the early absorption profile, variability, and comfort of phenobarbital given in microenema suspensions delivered via the Macy Catheter(®) (MC) vs.

The many faces of shugoshin, the "guardian spirit," in chromosome segregation.

Since it was first identified in Drosophila as a centromeric protein, MEI-S332/Shugoshin (Sgo1) has been an enigma. It is neither a kinase nor a phosphatase, but Sgo1's many functions are often attributable to protein-protein interactions that require Sgo1's presence to localize and/or function properly in a timely manner. Though much has been reported about Sgo1's role in ensuring proper genome segregation through its regulatory role in maintaining cohesion through protection of centromeric cohesin, several additional functions have been identified that are less well characterized.

Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.

The steroid hormone progesterone is a key modulator of the cellular processes associated with the maintenance and development of female reproductive function. The biological activity of this hormone is mediated by specific nuclear receptors located in target cell nuclei which upon activation are capable of modulating the transcriptional activity of promoters containing progesterone response elements. Abnormalities in the progesterone receptor (PR) signal transduction pathway are implicated in pathological states such as breast cancer, endometriosis, and uterine fibroids.