Health benefits of US light-duty vehicle electrification: Roles of fleet dynamics, clean electricity, and policy timing.

We present a dynamic perspective to quantify the air quality-related health impacts of the electrification of light-duty vehicles in the United States between 2022 and 2050. Using a fleet turnover model and future electricity generation mix scenarios, we compare ambitious vehicle electrification to fleet renewal relying on newer internal combustion engine vehicles, without electric vehicles. The model includes vehicle-level pollutant emission factors and a reduced complexity air quality and valuation model and covers direct (tailpipe, brake wear, and tire wear) and indirect (production of electricity and liquid fuels) emissions of NO, SO, PM, NH, and VOCs, with a breakdown at the county level to identify geographical disparities in the distribution of health impacts.

Residential proximity to conventional and unconventional wells and exposure to indoor air volatile organic compounds in the Exposures in the Peace River Valley (EXPERIVA) study.

Background: In a previous study located in Northeastern British Columbia (Canada), we observed associations between density and proximity of oil and gas wells and indoor air concentrations of certain volatile organic compounds (VOCs). Whether conventional or unconventional well types and phases of unconventional development contribute to these associations remains unknown.

Objective: To investigate the associations between proximity-based metrics for conventional and unconventional wells and measured indoor air VOC concentrations in the Exposures in the Peace River Valley (EXPERIVA) study samples.

Modelling spatial & temporal variability of air pollution in an area of unconventional natural gas operations.

Despite the growing unconventional natural gas production industry in northeastern British Columbia, Canada, few studies have explored the air quality implications on human health in nearby communities. Researchers who have worked with pregnant women in this area have found higher levels of volatile organic compounds (VOCs) in the indoor air of their homes associated with higher density and closer proximity to gas wells. To inform ongoing exposure assessments, this study develops land use regression (LUR) models to predict ambient air pollution at the homes of pregnant women by using natural gas production activities as predictor variables.

Developing Formative Strategies to Support Undergraduate Nursing Student's Learning in the Lab.

Background: Undergraduate nursing education consists of supporting students' learning about psychomotor skills. There is variation in strategies used to facilitate learning in the lab setting because there is no single accepted or preferred educational approach.

Method: Formative learning strategies were integrated into lab courses throughout a nursing curriculum for undergraduate students at a Canadian university.

The complex relationship between carbon literacy and pro-environmental actions among engineering students.

Lifestyle choices and consumption play a large role in contributing to per capita greenhouse gas emissions. Certain activities, like fossil fuel ground transportation, long-haul flights, diets with animal products and residential heating and cooling contribute significantly to per capita emissions. There is uncertainty around whether literacy about these actions encourages individuals to act pro-environmentally to reduce personal carbon footprints or to prioritize the most effective actions.

Estimating the environmental impacts of global lithium-ion battery supply chain: A temporal, geographical, and technological perspective.

A sustainable low-carbon transition via electric vehicles will require a comprehensive understanding of lithium-ion batteries' global supply chain environmental impacts. Here, we analyze the cradle-to-gate energy use and greenhouse gas emissions of current and future nickel-manganese-cobalt and lithium-iron-phosphate battery technologies. We consider existing battery supply chains and future electricity grid decarbonization prospects for countries involved in material mining and battery production.

Does E-learning Facilitate Medical Education in Pediatric Neurology?

Background: E-learning has become commonplace in medical education. Incorporation of multimedia, clinical cases, and interactive elements has increased its attractiveness over textbooks. Although there has been an expansion of e-learning in medicine, the feasibility of e-learning in pediatric neurology is unclear.

Novel use of an autologous scleral button graft to close the anterior defect in evisceration surgery.

Purpose: To present an alternative evisceration technique with long-term follow-up data. This technique involves the insertion of an acrylic implant into a modified scleral shell which is closed using an autologous scleral graft.

Methods: This was a retrospective analysis of eviscerations performed in a district-general hospital in the UK.

Understanding variability in petroleum jet fuel life cycle greenhouse gas emissions to inform aviation decarbonization.

A pressing challenge facing the aviation industry is to aggressively reduce greenhouse gas emissions in the face of increasing demand for aviation fuels. Climate goals such as carbon-neutral growth from 2020 onwards require continuous improvements in technology, operations, infrastructure, and most importantly, reductions in aviation fuel life cycle emissions. The Carbon Offsetting Scheme for International Aviation of the International Civil Aviation Organization provides a global market-based measure to group all possible emissions reduction measures into a joint program.

8-0 polyglactin 910 suture in entropion repair: long term follow up and rates of recurrence.

Objectives: The choice of suture is an important consideration in entropion repair, with implications on wound strength, inflammation and scar formation. There is no consensus on the best suture material or gauge of suture at present. We aim to assess the long-term outcome of entropion repair using 8-0 polyglactin sutures, with specific focus on rates of recurrence, wound dehiscence, infection and scarring.

Validating the automation of different measures of high temperature tolerance of small terrestrial insects.

Accurately phenotyping numerous test subjects is essential for most experimental research. Collecting such data can be tedious or time-consuming, and it can be biased or limited using manual observations. The thermal tolerance of small ectotherms is a good example of this type of phenotypic data, and it is widely used to investigate thermal adaptation, acclimation capacity and climate change resilience of small ectotherms.

More or less of me and you: self-relevance augments the effects of item probability on stimulus prioritization.

Self-relevance exerts a powerful influence on information processing. Compared to material associated with other people, personally meaningful stimuli are prioritized during decision-making. Further exploring the character of this effect, here we considered the extent to which stimulus enhancement is impacted by the frequency of self-relevant versus friend-relevant material.

Greenhouse Gas Emission Mitigation Pathways for Urban Passenger Land Transport under Ambitious Climate Targets.

Urban passenger land transport is an important source of greenhouse gas (GHG) emissions globally, but it is challenging to mitigate these emissions as this sector interacts with many other economic sectors. We develop the Climate change constrained Urban passenger Transport Integrated Life cycle assessment (CURTAIL) model to outline mitigation pathways of urban passenger land transport that are consistent with ambitious climate targets. CURTAIL uses the transport activity of exogenously defined modal shares to simulate the associated annual vehicle stocks, sales, and life cycle GHG emissions.

Serum Neurofilament Light Chain Measurement in MS: Hurdles to Clinical Translation.

Measurement of serum neurofilament light chain concentration (sNfL) promises to become a convenient, cost effective and meaningful adjunct for multiple sclerosis (MS) prognostication as well as monitoring disease activity in response to treatment. Despite the remarkable progress and an ever-increasing literature supporting the potential role of sNfL in MS over the last 5 years, a number of hurdles remain before this test can be integrated into routine clinical practice. In this review we highlight these hurdles, broadly classified by concerns relating to clinical validity and analytical validity.

Optimizing the Use of a Constrained Resource to Minimize Regional Greenhouse Gas Emissions: The Case Study of Slag in Ontario's Concrete.

Green policies currently incentivize concrete producers to replace portland cement with industrial byproducts to reduce their greenhouse gas (GHG) emissions. However, policies are based on attributional life cycle assessments (LCAs) that do not account for market constraints and consider byproducts either available burden-free to the user (cutoff approach) or partially responsible for the emissions generated in the upstream processes (allocation). The goal of this study was to investigate whether these approaches (and incentives) could lead to a mismanagement of byproducts and to suboptimal solutions in terms of regional GHG emissions.

A pilot study of a longitudinal mindfulness curriculum in undergraduate medical education.

Background: To support student well-being, a mindfulness curriculum in undergraduate medical education was launched at our university in 2014. We describe the program and report 3-year results.

Methods: Medical students responded to online questionnaires on mindfulness (Freiburg Mindfulness Inventory), empathy (Jefferson Scale of Physician Empathy), resilience (Connor-Davidson Resilience Scale) and perceived stress (Perceived Stress Scale) and were surveyed for demographics, home practice, and subjective experience at curriculum launch and yearly for 3 years.

Experiences and perceptions of spousal/partner caregivers providing care for community-dwelling adults with dementia: a qualitative systematic review.

Objective: The objective of this review was to synthesize evidence on the experiences and perceptions of spousal/partner caregivers of community-dwelling adults with dementia.

Introduction: Currently 47 million people in the world have a diagnosis of dementia, and this number is predicted to climb to 75 million by 2030. The majority of care is provided by family members, particularly spouses/partners.

Drawing the line: Linear or non-linear reaction norms in response to adult acclimation on lower thermal limits.

Estimates of lower thermal limits are widely used to infer sensitivity to climate variability, local adaptation and adaptive acclimation responses in ectotherms. These inferences build on the ecological relevance of the tolerance estimates and assume that estimates can be extrapolated to relevant conditions. Methodological effects for upper thermal limits have been extensively investigated, with different ramping rates and acclimation regimes giving rise to varying, and even disparate, conclusions.

Androgens stimulate erythropoiesis through the DNA-binding activity of the androgen receptor in non-hematopoietic cells.

Background: Androgens function through DNA and non-DNA binding-dependent signalling of the androgen receptor (AR). How androgens promote erythropoiesis is not fully understood.

Design And Methods: To identify the androgen signalling pathway, we treated male mice lacking the second zinc finger of the DNA-binding domain of the AR (AR ) with non-aromatizable 5α-dihydrotestosterone (5α-DHT) or aromatizable testosterone.

Neurotoxicity after hematopoietic stem cell transplant in multiple sclerosis.

Objective: Accelerated brain volume loss has been noted following immunoablative autologous hematopoietic stem cell transplantation (IAHSCT) for multiple sclerosis. As with other MS treatments, this is often interpreted as 'pseudoatrophy', related to reduced inflammation. Treatment-related neurotoxicity may be contributory.

Research-to-Practice Gaps in Multiple Sclerosis Care for Patients with Subjective Cognitive, Mental Health, and Psychosocial Concerns in a Canadian Center.

Background: People with multiple sclerosis (MS) are at increased risk for cognitive impairment, mental health concerns, and psychosocial issues, which can negatively affect disease outcomes and quality of life. Current MS care guidelines recommend integrated interdisciplinary services to address these concerns; however, issues can be overlooked during routine care. To date, there is inadequate research on how often these issues are identified and addressed during routine MS care.

Temperature preference across life stages and acclimation temperatures investigated in four species of Drosophila.

Ectotherms can use microclimatic variation and behavioral thermoregulation to cope with unfavorable environmental temperatures. However, relatively little is known about how and if thermoregulatory behavior is used across life stages in small ectothermic insects. Here we investigate differences between three specialized Drosophila species from temperate, tropical or desert habitats and one cosmopolitan species by estimating the preferred temperature (T) and the breadth (T) of the distribution of adults, adult egg-laying, and larvae in thermal gradients.

Environmental Aspects of Biotechnology.

A key motivation behind the development and adoption of industrial biotechnology is the reduction of negative environmental impacts. However, accurately assessing these impacts remains a formidable task. Environmental impacts of industrial biotechnology may be significant across a number of categories that include, but may not be limited to, nonrenewable resource depletion, water withdrawals and consumption, climate change, and natural land transformation/occupation.

Evolution and plasticity of thermal performance: an analysis of variation in thermal tolerance and fitness in 22 Drosophila species.

The thermal biology of ectotherms is often used to infer species' responses to changes in temperature. It is often proposed that temperate species are more cold-tolerant, less heat-tolerant, more plastic, have broader thermal performance curves (TPCs) and lower optimal temperatures when compared to tropical species. However, relatively little empirical work has provided support for this using large interspecific studies.