Editors' Review and Introduction: Models of Rational Proof in Criminal Law.

Decisions concerning proof of facts in criminal law must be rational because of what is at stake, but the decision-making process must also be cognitively feasible because of cognitive limitations, and it must obey the relevant legal-procedural constraints. In this topic three approaches to rational reasoning about evidence in criminal law are compared in light of these demands: arguments, probabilities, and scenarios. This is done in six case studies in which different authors analyze a manslaughter case from different theoretical perspectives, plus four commentaries on these case studies.

A Scenario Approach to the Simonshaven Case.

In this paper, we present a scenario approach and apply it to the Simonshaven case. We offer an outline in which we spell out the core notions of the scenario approach. Next, we give a summing up of criteria to assess and compare scenarios.

Evaluating the Quality of the Deliberation in Moral Case Deliberations: A Coding Scheme.

Moral Case Deliberation (MCD) is an up and coming form of ethics support wherein clinical professionals deliberate about moral questions they face in their work. So far, it has been unclear what quality of deliberation in MCD is entailed and how to evaluate this quality. This article proposes a coding scheme that fits the theoretical background of MCD and allows researchers to evaluate the quality of the deliberation in MCDs.

Whole blood and plasma water in health and disease: longitudinal and transverse observations and correlations with several different hematological and clinicochemical parameters.

In a healthy reference population, hemoglobin (Hgb) and hematocrit (Hct) have been proposed as surrogate markers for whole blood water (WBW). We have extended this study under different physiological and pathological conditions in two longitudinal series, viz. (1) acute hyper- and hypohydration experiments in a healthy individual and (2) three athletes running 5 km each, and in three transverse series, viz.

Gravimetric determination of the water concentration in whole blood, plasma and erythrocytes and correlations with hematological and clinicochemical parameters.

We have assessed gravimetric methods for determination of intravascular water, established whole blood-, plasma- and erythrocyte water reference values in a healthy volunteer group (n = 97, 48 females) and correlated these variables with 30 simultaneous hematological, clinicochemical and body parameters. The water standard was 55.56 mol/kg = 100 mass %.

The diagnostic power of the tests for tear gland related keratoconjunctivitis sicca.

Laboratory tear function tests, such as the lactoferrin and the lysozyme test, reflect the level of tear gland deficiency and are, therefore, very useful for the clinician in the diagnosis of keratoconjunctivitis sicca (KCS). Although these tests do have an excellent discriminatory ability, they should be used in addition to clinical tests, such as the Schirmer-1 test, the tear film break-up time (BUT) and the Rose bengal (Rb) staining test. Schirmer's test, the most commonly used clinical test, measures tear fluid production.

Sjögren's syndrome and tear function parameters.

In a group of patients with keratoconjunctivitis sicca associated with Sjögren's syndrome, the Schirmer values were lower in the Sjögren group of patients in comparison with a comparable group in which KCS was not associated with any systemic disease and these differences reached almost statistical significance. But a significant decrease in tear fluid lactoferrin concentration and tear film break-up time was demonstrated. The combination of the tear fluid lactoferrin concentration, the Schirmer I test values and the tear film break-up time provides a basis for differential diagnosis that is of some value clinically.

Tear function parameters in keratoconjunctivitis sicca with and without the association of Sjögren's syndrome.

In a group of patients with keratoconjunctivitis sicca (KCS) associated with Sjögren's syndrome (SJ) a significant decrease in tear fluid lactoferrin concentration and tear film break-up time was demonstrated in comparison with a matched group in which KCS was not associated with any systemic disease. The Schirmer values were also lower in the SJ of patients and these differences almost reached statistical significance. None of these parameters in itself appeared to be of any clinical value to differentiate between KCS that was or was not associated with SJ.