Publications by authors named "Mackenzie Wehner"
Frequency and timing of multiple skin cancer development in five cohorts.
J Am Acad Dermatol
February 2025
Background: Many patients will develop more than one skin cancer; however, most research to date has examined only case status.
Objective: Describe the frequency and timing of the treatment of multiple skin cancers in individual patients over time.
Methods: We conducted a longitudinal claims and electronic health record-based cohort study to examine the frequency of skin cancer multiplicity.
Article Synopsis
- The study examined the use of immune checkpoint inhibitors (ICIs) for treating advanced melanoma in patients aged 65 and older, focusing on demographic and neighborhood factors.
- Utilizing a sample of 3,531 SEER-Medicare beneficiaries from 2011-2017, the research analyzed ICI initiation rates using logistic regression.
- Findings revealed that male patients and those in areas with more oncologists were more likely to receive ICIs, while older age and higher comorbidity scores decreased the likelihood, although these disparities lessened in the later years of the study.
Article Synopsis
- Sexual minority (SM) individuals show varying rates of skin cancer compared to heterosexual individuals, with notable differences across racial and ethnic groups.
- The study analyzes data from over 1.5 million US adults to determine the lifetime prevalence of skin cancer among different sexual orientations and races.
- Results indicate that SM males have a higher skin cancer prevalence than heterosexual males, particularly among Hispanic and non-Hispanic Black males, while SM females show lower prevalence compared to their heterosexual counterparts.
Importance: Many patients will develop more than one skin cancer, however most research to date has examined only case status.
Objective: Describe the frequency and timing of the treatment of multiple skin cancers in individual patients over time.
Design: Longitudinal claims and electronic health record-based cohort study.
Some antihypertensive medications are photosensitizing. The implications for skin cancer risk remain unclear because results from prior studies are inconsistent and as new evidence is published. We performed a systematic review and meta-analysis to evaluate the association between antihypertensives and common skin cancers (cutaneous squamous cell carcinoma, basal cell carcinoma, and melanoma) and to evaluate dose-response relationships.
View Article and Find Full Text PDFThis manuscript uses individual-level data from 5 million Medicare beneficiaries to investigate the risks of melanoma in skin of color patients with a history of keratinocyte carcinoma. Despite worse melanoma outcomes, skin of color patients are often excluded from skin cancer literature. We found that skin of color patients with a history of keratinocyte carcinoma are at a significantly increased risk of melanoma, though their absolute risk is low.
View Article and Find Full Text PDFImportance: Actinic keratoses (AK) are common premalignant skin lesions with a small risk of progressing to cutaneous squamous cell carcinoma (SCC). There is some evidence that patients with AKs also have increased risks of other skin cancers beyond SCC. However, the absolute risks of skin cancer in patients with AKs are unknown.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma, but racial disparities in melanoma outcomes continue. These inequities are not fully explained by individual factors. To investigate the associations of neighborhood factors with the use of ICIs in metastatic melanoma.
View Article and Find Full Text PDFArticle Synopsis
- Indoor tanning beds lead to over 450,000 new skin cancer cases each year, with a 10.4% global prevalence among users, prompting the need for effective public health messaging on platforms like Instagram.* -
- A public health campaign on Instagram targeted young women and men at high risk for indoor tanning, featuring 34 ads and reaching over 1 million individuals, with significant engagement on the health information landing page.* -
- Despite high ad exposure and website visits, the campaign did not result in measurable changes in foot traffic to tanning salons, indicating a need for further research to assess effectiveness.*
Background: Cardiovascular disease (CVD) and cancer share several risk factors. Although preclinical models show that various types of CVD can accelerate cancer progression, clinical studies have not determined the impact of atherosclerosis on cancer risk.
Objectives: The objective of this study was to determine whether CVD, especially atherosclerotic CVD, is independently associated with incident cancer.
Importance: The number of advanced practice clinicians (APCs, including nurse practitioners and physician assistants) in the US is increasing. The effect this has on dermatology is unclear.
Objective: To develop a method to identify APCs practicing dermatology in claims data and to evaluate the contribution of dermatology APCs to the dermatology workforce and how this has changed over time.
Importance: The use of second-generation antiandrogens (AAs) in the treatment of prostate cancer is increasing. Retrospective evidence suggests an association between second-generation AAs and adverse cognitive and functional outcomes, but further data from prospective trials are needed.
Objective: To examine whether evidence from randomized clinical trials (RCTs) in prostate cancer supports an association between second-generation AAs and cognitive or functional toxic effects.
Importance: Keratinocyte carcinomas are the most common cancers in the US. However, keratinocyte carcinomas are not included in US national cancer registries, and information on the anatomic locations of keratinocyte carcinomas is lacking.
Objective: To investigate the anatomic location of keratinocyte carcinomas in the US using a large claims data set.