Publications by authors named "Mackenzie O'Brien"

Article Synopsis
  • Excessive vitamin D supplementation can lead to toxicity, which is uncommon but can cause serious symptoms primarily due to high calcium levels in the blood (hypercalcemia).
  • A case study is presented involving a young child who developed posterior reversible encephalopathy syndrome (PRES) alongside complications like high blood pressure, acute kidney failure, and respiratory issues, all linked to vitamin D toxicity.
  • This report aims to educate healthcare providers about the potential severe effects of high vitamin D levels in children and stresses the need for proper safety guidelines for vitamin supplementation among families.
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Age-related macular degeneration (AMD) is a debilitating eye disease that tends to affect people over the age of 55. Lipofuscins are autofluorescent, toxic byproducts of the visual cycle thought to contribute toward the progression of the disease. Targeting the accumulation of lipofuscin through catabolism may serve as a method for the early treatment of AMD.

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