Publications by authors named "Mackenzie C Obenreder"
Cell Mol Bioeng
February 2023
Article Synopsis
- Obesity is linked to higher rates of breast cancer incidence, recurrence, and death, with specific cells in fat tissue (adipocytes and ASCs) contributing to early cancer progression.
- Researchers created models of human breast tumors with fat tissue showing various changes due to obesity to study how cancer cells escape into circulation.
- The study found that both lean and obese fat cells equally sped up the escape of breast cancer cells, indicating that the presence of these fat cells, regardless of obesity, enhances cancer cell mobility.
Cell Mol Bioeng
February 2022
Article Synopsis
- About 20-25% of breast tumors occur in adipose stroma, which is linked to higher lymph node metastasis, although the reasons for this connection are not fully understood.
- Researchers created small breast tumors in a gel containing both fat cells and stem cells to mimic how cancer cells invade and escape into lymphatic vessels.
- Results showed that these adipose cells sped up cancer cell invasion and escape, primarily due to factors released by the stem cells, highlighting the role of adipose stroma in breast cancer metastasis.
