Collisional dampening for improved quantification in single particle inductively coupled plasma mass spectrometry.

Inductively coupled plasma mass spectrometry (ICP-MS) is a powerful method for detection and quantification of nanoparticles. Unfortunately, the linear dynamic range of single particle analysis is hindered by "unruly" transient signals, momentary pulse pile-ups at the electron multiplier detector. This study seeks to extend the dynamic range of ICP-MS nanoparticle quantification via addition of a collision gas in the collision cell of the ICP-MS.