Temporal alterations of the nascent proteome in response to mitochondrial stress.

Under stress, protein synthesis is attenuated to preserve energy and mitigate challenges to protein homeostasis. Here, we describe, with high temporal resolution, the dynamic landscape of changes in the abundance of proteins synthesized upon stress from transient mitochondrial inner membrane depolarization. This nascent proteome was altered when global translation was attenuated by stress and began to normalize as translation was recovering.

Development of effective potassium acetate extractant.

Carboxylates are commonly used in the food and pharmaceutical industry and due to their extensive use, carboxylates present a significant environmental burden. In this context, valine based, heteroditopic receptor 1 was prepared and its ability to bind simultaneously potassium cation and acetate anion in water containing CHCN solutions was demonstrated. Under liquid-liquid extraction conditions the receptor 1 was capable of extracting hydrophilic AcOK salt from aqueous solution and was proved to be nearly ten times more effective than the equimolar mixture of monotopic receptors.

Clinical Characteristics of Hypertensive Patients with Obstructive Sleep Apnoea Syndrome Developing Different Types of Left Ventricular Geometry.

Objective: The objective of the study was to compare polygraphic parameters and selected laboratory parameters in patients with obstructive sleep apnoea (OSA) who develop various types of left ventricular (LV) geometry. . The research covered 122 patients with obstructive sleep apnoea and coexisting effectively treated systemic hypertension (95 men, 27 women, average age: 54 ± 10.

Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis.

Introduction: Alcohol consumption causes acute and chronic liver injury. The clinical forms of alcohol liver disease (ALD) include steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) associated with liver cirrhosis.

Objective: The aim of the study was to determine the levels of novel markers of fibrogenesis and angiogenesis in patients with alcoholic liver cirrhosis.

Complexation of 5-aminovaleric acid zwitterions in aqueous/methanol solution by heterotopic tri-cationic receptors.

Heterotopic tri-cationic receptors based on 4,10,16-triaza-18-crown-6 are capable of efficient and selective binding of the zwitterionic form of 5-aminovaleric acid (5-AVA) in aqueous/methanol solution. The cooperative participation of both cation and anion binding domains of this receptor in 5-AVA complexation was established by H NMR experiments and DFT calculations. Heterotopic receptors and fluorescein were used for the preparation of indicator displacement assay and this assembly was applied to selective optical sensing of 5-aminovaleric acid.

Obstructive sleep apnea may increase the risk of Alzheimer's disease.

Objectives: Amyloid-β 1-40 (Aβ 1-40) and amyloid-β 1-42 (Aβ 1-42) are the proteins known to be involved in the pathogenesis of Alzheimer's disease (AD)-the most common cause of dementia in the elderly. Hypoxia is suspected to be one of conditions associated with Aβ plasma level increase. A common reason of hypoxia is obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea.

A non-multimacrocyclic heteroditopic receptor that cooperatively binds and effectively extracts KAcO salt.

Prepared in only three synthetic steps, a non-multimacrocyclic heteroditopic receptor binds potassium salts of halides and carboxylates with unusually high cooperativity, suggesting salt binding as associated ion-pairs. Unprecedented extraction of highly hydrophilic KAcO salt from water to organic solution is also demonstrated.

An ion-pair receptor comprising urea groups and N-benzyl-aza-18-crown-6: effective recognition and liquid-liquid extraction of KCl salt.

Compound 1 was designed and prepared as a heteroditopic ion-pair receptor that contains two urea groups for anion complexation and N-benzyl-18-crown-6 for cation recognition. These ion-binding domains are assembled together by the l-ornithine scaffold. Qualitative cation coordination studies of receptor 1, supported by quantitative data received for monotopic N-(3-nitrobenzyl)-aza-18-crown-6 (3a), have shown that 1 has a strong affinity for Na, K and NH cations.

Spatial QRS-T angle in patients with newly diagnosed obstructive sleep apnea syndrome.

Purpose: The aim of the study was to assess the spatial QRS-T angle (QRS-TA) in a group of newly diagnosed and untreated adult patients with obstructive sleep apnea syndrome (OSAS) and to identify potential factors affecting this parameter.

Patients And Methods: The study group (PSG-confirmed OSAS) included 62 individuals, aged 51.7±10.

Reliability of the Epworth Sleepiness Scale and the Berlin Questionnaire for screening obstructive sleep apnea syndrome in the context of the examination of candidates for drivers.

Background: The aim of the study has been to assess the usefulness of the Epworth Sleepiness Scale (ESS) and the Berlin Questionnaire (BQ) for obstructive sleep apnea syndrome (OSAS) screening. The capacity of both tests to discriminate between healthy individuals or with mild OSAS (apnea-hypopnea index (AHI) < 15/h) vs. patients with moderate or severe OSAS (AHI ≥ 15/h) was evaluated.

Evaluation of Fibrinolytic Inhibitors: Alpha-2-Antiplasmin and Plasminogen Activator Inhibitor 1 in Patients with Obstructive Sleep Apnoea.

Obstructive sleep apnoea (OSA) induces thrombophilia and reduces fibrinolysis. Alpha-2-antiplasmin (a-2-AP) and plasminogen activator inhibitor 1 (PAI-1) are major inhibitors of the fibrinolytic system. Increased concentrations of these factors are associated with a higher risk of cardiovascular diseases.

Highly effective ion-pair receptors based on 2,2-bis(aminomethyl)-propionic acid.

Compounds 2 and 3 were designed and prepared as heteroditopic ion-pair receptors. The design features a 2,2-bis(aminomethyl)propionic acid core to connect and pre-organize binding groups. The cation binding is provided by a sodium selective N-acyl aza-18-crown-6 subunit whereas for anion complexation, two urea groups (receptor 2) or two squaramide groups (receptor 3) were introduced.

[Evaluation of the intracellular expression of interleukin 17 in patients with ovarian cancer].

Unlabelled: Knowledge of the role of interleukin 17 (IL-17) has led to the identification of new subpopulation of T helper lymphocytes--Th17 and T cytotoxic lymphocytes secreting IL-17 (Tc17). An increasing amount of attention is paid to their role in anti-tumor immunity.

Aim: The aim of this study was to evaluate the percentage of peripheral blood, peritoneal fluid and cancer tissue CD4+ and CD8+ T lymphocytes producing IL-17 in patients with ovarian cancer

Material And Methods: Forty patients operated due to advanced ovarian carcinoma and twenty-four patients with functional follicle ovarian cysts were recruited.

[Epidemiological trend in rotavirus infections in children hospitalized in the Department of Paediatrics at Warsaw Bielany Hospital; 2005-2007].

Aim: defining the epidemiological trend in community acquired and nosocomial rotavirus infections in children hospitalized in the Department of Paediatrics of the Warsaw Bielany Hospital; 2005-2007. Assessment of the correlation with respect to age, sex and month of the year.

Materials: we reviewed 1126 case histories of patients age from 1 month to 16 years (median 19 months) admitted to the Hospital because of vomiting and diarrhea.

[The influence of Sudden Infant Death Syndrome (SIDS) risk factors on health, growth and development in the first year of life. A preliminary report].

Aim: To establish the occurrence of SIDS risk factors (including 'removable' ones) and the incidence of the ecg long QT interval (accepted as a risk factor) and their influence upon infants development and morbidity.

Material And Methods: A group of 98 infants from normal birth at term to the end of first year of life was observed. The data sources were as follows: 1) a questionnaire filled by mothers before discharge front maternity ward, 2) records of four consecutive medical examinations (including ecg records) performed on 3rd day and 3rd, 6th and 12th month of life.