Publications by authors named "Maciej Spalek"
Background/objectives: Pemphigus comprises a diverse group of disorders within the autoimmune bullous dermatoses (AIBDs) spectrum. Among these, pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are the most commonly encountered variants. Despite its rarity, this condition can pose a life-threatening risk.
View Article and Find Full Text PDF: Dapsone (DP) is employed in the management of various skin conditions, including autoimmune bullous diseases to non-enzymes (n-eAIBDs). This study aimed to assess the advantages and safety profile of DP treatment in n-eAIBDs patients. The evaluation focused on clinical remission, reduction in glucocorticosteroid (GCS) usage, and adverse incidents during a 12-month observation in a dermatology department at a Central European university.
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- Rituximab (RTX) is primarily used to treat autoimmune bullous diseases (AIBDs), and this research evaluated its benefits and safety in patients over a year-long period.
- In the study involving 11 patients with various AIBDs, significant reductions in steroid (prednisone) use and autoantibody levels were observed following RTX treatment.
- While 18% of patients had disease relapses, most achieved remission with minimal therapy, and adverse effects were mild, indicating RTX is a promising option for managing refractory AIBD, though further research on dosage and maintenance is needed.
Article Synopsis
- * Out of 462 Slavic patients with AIBD, only 21 (12 females and 9 males) showed palmoplantar involvement, with no significant differences in occurrence across different AIBD categories.
- * The findings suggest that while palm and sole lesions are rare, their presence can be clinically important, especially in diagnosing lichen planus pemphigoides (LPP) and epidermolysis bullosa acquisita (EBA).
Article Synopsis
- - The study evaluated high-dose intravenous immunoglobulin (IVIG) therapy for treating autoimmune bullous diseases (AIBDs), focusing on clinical remission, glucocorticosteroid reduction, and safety over 12 months.
- - A group of 10 patients with various types of AIBDs received IVIG infusions, resulting in significant reductions in prednisone dosage and overall improvements in disease status; however, 20% of patients experienced relapse.
- - While IVIG therapy showed effectiveness and an acceptable safety profile with mostly mild side effects, its high cost poses challenges for accessibility, especially in low-income areas, making it a consideration for patients who can't use standard treatments.
Introduction: Hypertension is considered to be the most common pathology of the circulatory system and the most common cause of death or cardiovascular diseases' development. There are many commonly known risk factors of this condition, such as overweight, obesity, a high-fat diet, family history of ischemic heart disease, lipid disorders, and atherosclerosis. In order to reduce the effect of high blood pressure, patients should modify their lifestyle, including sleeping patterns.
View Article and Find Full Text PDFThe influence of meal frequency on lipid profile in the Polish population.
Neuro Endocrinol Lett
December 2019
Objectives: Despite numerous investigations, the influence of meal frequency on the lipid profile has not been clearly determined. The aim of the study was to investigate whether meal frequency corresponds with the lipid profile.
Material And Methods: The cross-sectional study enrolled 495 patients of University Hospital of Lord's Transfiguration who met inclusion criteria for study treated in 2015-2017.
Arterial Stiffness Parameters Correlate with Estimated Cardiovascular Risk in Humans: A Clinical Study.
Int J Environ Res Public Health
July 2019
Arterial stiffness is said to be a novel predictor of cardiovascular events. This study investigated the correlation between arterial stiffness parameters and the estimated cardiovascular disease risk (RISK) in a Polish cohort of patients divided by age, sex, and body-mass index (BMI). The cross-sectional study enrolled 295 patients who met the inclusion criteria.
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