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Publications by authors named "Maciej Sobczak"

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Synopsis of recent research by authors named "Maciej Sobczak"

  • - Maciej Sobczak's recent research primarily focuses on the mechanisms of drug resistance in cancer cells, particularly looking at ATP-binding cassette (ABC) transporters and their impact on the efficacy of chemotherapy drugs like cisplatin and paclitaxel.
  • - His studies demonstrate that the CBP/EP300 bromodomain inhibitor I-CBP112 can reverse drug resistance by downregulating ABC transporter expression in resistant cell lines, enhancing drug accumulation and cytotoxicity, which could potentially improve treatment outcomes for patients with triple-negative breast cancer and non-small cell lung cancer.
  • - Additionally, Sobczak explores the role of epigenetic regulators such as BRG1 and PARP1 in cancer cell proliferation, transcriptional control, and the pro-inflammatory polarization of macrophages, highlighting their significance in the development and treatment of various cancer-related conditions.

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