Effect of subacute poisoning with lambdacyhalothrin on vascular endothelial growth factor 2 receptor in mice kidneys.

Background: Pyrethroids are used for insect control. They act on voltage-gated sodium channels in neurons. Lambdacyhalothrin (LCH) is a type II pyrethroid producing choreoatetosis and salivation in rodents.

Oxidative stress in colonic adenocarcinoma: An impact on the body's antioxidative status and oxidative protein damage.

Background: Thus far, the pathogenesis of these intestinal tumors has not been fully explained. However, the analysis of risk factors and research regarding their formation that have continued for 3 decades have allowed us to demonstrate a significant role of oxidative stress in the processes leading to the development of cancer in the large intestine as well as in some other organs.

Objectives: The aim of the study was to examine the level of anti-oxidative status and the degree of oxidative protein damage in patients with varying severity of colonic adenocarcinoma (CAC) in relation to healthy individuals.

The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study.

Background: The increasing incidence of metabolic diseases such as obesity or diabetes have made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species, which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among the non-enzymatic mechanisms counteracting this phenomenon.

Impact of electromagnetic radiation emitted by monitors on changes in the cellular membrane structure and protective antioxidant effect of vitamin A - In vitro study.

Objectives: The increasing number of devices emitting electromagnetic radiation (EMR) in people's everyday life attracted the attention of researchers because of possible adverse effects of this factor on living organisms. One of the EMR effect may be peroxidation of lipid membranes formed as a result of free radical process. The article presents the results of in vitro studies aimed at identifying changes in malondialdehyde (MDA) concentration - a marker of lipid peroxidation and antioxidant role of vitamin A during the exposure of blood platelets to electromagnetic radiation generated by liquid-crystal-display (LCD) monitors.

Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study.

Background: Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans.

The effect of electromagnetic radiation emitted by display screens on cell oxygen metabolism - in vitro studies.

Introduction: Research studies carried out for decades have not solved the problem of the effect of electromagnetic radiation of various frequency and strength on the human organism. Due to this fact, we decided to investigate the changes taking place in human blood platelets under the effect of electromagnetic radiation (EMR) emitted by LCD monitors.

Material And Methods: The changes of selected parameters of oxygen metabolism were measured, i.

[Physical activity in patients with symptoms of metabolic syndrome reduces the concentration of plasma antioxidant vitamins - protective effect of vitamin C].

Unlabelled: Patients with cardiovascular diseases, including those with the symptoms of metabolic syndrome (MS), are recommended regular exercise but many studies indicate its role in the production of reactive oxygen species. Vitamin C supplementation may enhance the antioxidant barrier in MS patients.

Aim: The aim of the study was to assess the impact of regular physical activity (PA)and vitamin C supplementation on plasma vitamin A, C and E levels in patients with MS.

[Estimation of plasma vitamin A, C and E levels in patients with metabolic syndrome].

Unlabelled: Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting development of cardiovascular diseases. In the pathogenesis of MS there participate reactive oxygen species which are excessively produced in such elements of MS as hyperglycemia, insulin resistance and obesity. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans.

[The impact of ascorbic acid on the concentrations of antioxidative vitamins in the plasma of patients with non-small cell lung cancer undergoing first-line chemotherapy].

Unlabelled: One of the main after-effects of chemotherapy used in cancer treatment is an augmented production of reactive oxygen species (ROS). In turn ROS become a source of unwanted side effects of chemotherapy, often forcing the discontinuation of the therapy. Ascorbic acid (vitamin C), being an antioxidant, can strengthen the antioxidative barrier of an organism.

[Assessment of concentrations of A, C and E vitamins in the plasma of patients with NSCLC undergoing first-line chemotherapy].

Unlabelled: Lung cancer is one of the most common cancer types and it usually takes the form of non-small cell lung cancer (NSCLC). ROS take part in the process of carcinogenesis. What more, chemotherapy used in cancer treatment augments their production, leading to the weakening of the antioxidative barrier.

Adverse effects of antioxidative vitamins.

High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-term basis in numerous preventive and therapeutic medical applications. Instead of expected health effects, the use of those vitamins may however lead to cases of hypervitaminosis and even to intoxication. The article points out main principles of safety which are to be observed during supplementation with antioxidative vitamins.

[Vitamins E, A and C as antioxidatives].

It has been found during last years that vitamins A, C, E and carotenoids, besides previously recognized functions of preventing particular lipido- and avitaminosis, significantly participate in the protection of the human body against oxidation stress that is characterized by balance disturbance between speed of free radical creation and reactive oxygen forms with pace of their neutralization by enzymes and antioxidants. The antioxidative system creates special protective barrier which includes numerous chemical form with antiperoxidative proprieties and vitamins are the most important part of it. The aim of this work was the profile of occurrence and antioxidative action of the vitamins A, C and E.

[Testing antineoplastic activity of new platinum(II) and palladium(II) complex compounds].

Unlabelled: A pyrazole system is incorporated in many biological molecules which play an important part in genetic processes. It seems that co-ordinating biological molecules, which would serve as carriers, should contribute to minimising the toxic effects of the potential platinic drugs.

Aim Of The Study: Assessment of in vivo biological activity, and in particular of antineoplastic activity of new platinum(II) and palladium(II) complexes.

[In vitro biological activity of new platinum(II) and palladium(II) complex compounds].

Unlabelled: A nitrogen ring is present in many biological molecules, which play an important part in cell division as well as in genetic information transfer. It is also a part of the purine system, which builds DNA and has potential places/spots of platinum drug co-ordination. Therefore, it may be hoped, that platinum(II) complexes with diazol ligands will have considerable affinity for DNA binding sites.

[Derivatives pyrazoles used in a medical treatment].

Contemporary coordinative chemistry is still searching new substances that might constitute good ligands for transient metal ions: Cu(II), Ni(II), Co(II), Pt(II), Pd(II) oraz Cr(III). Pyrazole and its derivatives are able to make complexes with transient metal ions. There is a connection between pharmacological and chemical structure among pyrazole derivatives used in a medical treatment.

[Antioxidative defense and level of microelements in youth with hypertension].

Unlabelled: In recent years we observed increased interest of free radical processes accompanying varying physiological and pathological reactions. THE AIM OF THIS STUDY was an evaluation some of serum microelements (zinc, manganium, chromium, selenium) in serum and antioxidative defense in youth with hypertension.

Material And Methods: The group of 88 youth aged 9-18 with normal blood pressure, prehypertension and hypertension was examined.

[Participation of reactive oxygen species in muscle damage produced by hypokinesis].

The big problem of high-developed community is hypokinesis - clinical state generated by long-lasting immobilization. Virtually all body systems are affected by immobilization. Hypokinesis intensify production of reactive oxygen species (ROS).

[The influence of the increasing doses of vitamin C on the concentration of the substance reacting with thiobarbituric acid (TBARS) in mice liver].

Ascorbic acid is known antioxidant protecting many organs and tissues. In some circumstances can act as prooxidant, particullary when coexists with high concentration of ferrum and copper jons. Condition like that can take place for example in liver.

[The estimation of antioxidative vitamins concetrations in blood plasma of patients with neoplasms of gallblader and biliary tract].

Gallbladder and biliary tract cancer is a serious clinical problem. In-spite of wide range of new diagnostic and therapeutic methods, the significant improvement of treatment results, has not been noticed so far. The research about prevention methods, seems to be important, among the ways of improvement of the diagnosis and therapy outcomes of these diseases.

Evaluation of bone mineral density on the basis of the results of studies of selected skeleton populations from the microregion of Brześć Kujawski.

Introduction: Osteoporosis is a systemic disease of the skeletal system characterised by reduced bone strength leading to increased risk of fracture. Bone strength is a combined derivative of bone mineral density (BMD) and of bone tissue quality. Osteoporosis is a serious medical problem because of its complications, most frequently manifesting itself in spine fractures, fractures of distal sections of the forearm and, in later periods of life, hip fractures.

[Antioxidative properties of vitamin E as a new approach to its applications in therapy].

The article presents current state of knowledge about antioxidative action of vitamin E, enabling significant broadening of its possible application in medicine. Mechanisms are discussed due to which it takes a very important part in protection of an organism against effects of oxidative stress. Followed from here consequences of this vitamin deficiencies were indicated.

[Contribution and role of important biochemic factors in cerebral ischemia].

After an ischemic insult, a multi-faceted complex cascade of biochemical reactions occurs that ultimately causes neurons death. Above reactions exert an influence on: immunological changes (activation of the complement system and the generation of antibodies), increased inflammation (actions of proinflammatory cytokines and chemokines), the production of reactive oxygen species leading to oxidative stress, diminished mitochondrial function and activation of apoptotic pathways. There is also intensive release and wrong reversible escapement many of neurotransmitters.

[The influence of anthocyanins from Aronia melanocarpa on selected parameters of oxidative stress and microelements contents in men with hypercholesterolemia].

The Aim Of The Study: Our investigations was to estimate the influence of Aronia anthocyanins (Aronox by Agropharm) on selected parameters of oxidative and antioxidative balance as well as on the concentration of selected metals in red blood cells in men with hipercholesterolaemia.

Material And Methods: 16 men aged 27 +/- 6.4 years old with blood cholesterol concentration on the level of 205-250 mg/dl took 240 mg of anthocyanins a day for 30 days.

[The biomedical aspects of the non-antioxidative action of vitamin E and its resulting role in therapy].

The review of current informations connected with the non-antioxidative applications of vitamin E in therapy was performed. After explanation indispensable structural and nomenclatural questions, were have talked over was for above mentioned uses: biological activity of this vitamin, food sources and the metabolism. It was presented the systemic non-antioxidative functions and the resulting actions from here with range of prevention.