Publications by authors named "Maciej Maciuszek"
Gene expression is regulated by controlling distinct steps of the transcriptional cycle, including initiation, pausing, elongation, and termination. Kinases phosphorylate RNA polymerase II (RNA Pol II) and associated factors to control transitions between these steps and to act as central gene regulatory nodes. Similarly, phosphatases that dephosphorylate these components are emerging as important regulators of transcription, although their roles remain less well understood.
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- Plasmodium falciparum's RH5 protein is a promising candidate for a malaria vaccine, and understanding the antibody response during natural infections is crucial for optimizing vaccine efficacy.
- Researchers found that B cells reacting to RH5 were uncommon, and the IgG responses in malaria-exposed individuals were short-lived despite multiple infections.
- Some antibodies from malaria-exposed individuals showed strong neutralizing ability and targeted similar sites as the most effective vaccine-induced antibodies, indicating that natural infections might enhance the effectiveness of RH5 vaccines in the future.