The intrinsic sources of mortality relate to the ability to meet the metabolic demands of tissue maintenance and repair, ultimately shaping ageing patterns. Anti-ageing mechanisms compete for resources with other functions, including those involved in maintaining functional plasma membranes. Consequently, organisms with smaller cells and more plasma membranes should devote more resources to membrane maintenance, leading to accelerated intrinsic mortality and ageing.
View Article and Find Full Text PDFPLOS Glob Public Health
August 2022
Community health worker (CHW) programs are essential for expanding health services to many areas of the world and improving uptake of recommended behaviors. One of these programs, called Accredited Social Health Activists (ASHA), was initiated by the government of India in 2005 and now has a workforce of about 1 million. ASHAs primarily focus on improving maternal and child health but also support other health initiatives.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2023
We leverage metadata on over 36 million journal articles and reviews indexed by Scopus in order to estimate migration of scholars based on information on changes in their institutional affiliations over time. We produce a database of yearly international migration flows of scholars, for all countries from 1998 to 2017. We use the open-access database to provide descriptive evidence on the relationship between economic development and the emigration propensity of scholars.
View Article and Find Full Text PDFBackground: Work on the Act on the Profession of Physiotherapist had been conducted since the 1990s. However, it was not until October 2015 that the legal regulations were eventually introduced, following which physiotherapists gained professional independence and became a profession of public trust. The aim of the study was to assess the factors influencing the knowledge of these legal regulations among physiotherapists.
View Article and Find Full Text PDFWhen a recurrent event process is ended by death, this may imply dependent censoring if the two processes are associated. Such dependent censoring would have to be modeled to obtain a valid inference. Moreover, the dependence between the recurrence process and the terminal event may be the primary topic of interest.
View Article and Find Full Text PDFRecognising the nature of the predation risk, and responding to it accurately, is crucial to fitness. Yet, even the most accurate adaptive responses to predation risk usually entail costs, both immediate and lifelong. Rooting in life-history theory, we hypothesize that an animal can perceive the nuances of prey size and age selectivity by the predator and modulate its life history accordingly.
View Article and Find Full Text PDFThere is a trade-off between reproductive effort and adult longevity, and when resource allocation is taken into account, it is especially pronounced in species that have aphagous adult forms. This trade-off may be further complicated by environmental factors such as nutrient availability during larval development and by the other sex, which influences the costs of reproduction due to the presentation of nuptial gifts. Here, we examined the influence of larval nutrient quantity on the sex-specific longevity costs of reproduction in the gift-giving seed beetle Callosobruchus maculatus.
View Article and Find Full Text PDFResearch indicates that women have higher levels of physical disability and depression and lower scores on physical performance tests compared to men, while the evidence for gender differences in self-rated health is equivocal. Scholars note that these patterns may be related to women over-reporting and men under-reporting health problems, but gender differences in reporting behaviors have not been rigorously tested. Using Wave 1 of the Survey of Health, Ageing and Retirement in Europe (SHARE), the present study investigates the extent to which adjusting for differences in reporting behavior modifies gender differences in general health.
View Article and Find Full Text PDFThe Williams' hypothesis is one of the most widely known ideas in life history evolution. It states that higher adult mortality should lead to faster and/or earlier senescence. Theoretically derived gradients, however, do not support this prediction.
View Article and Find Full Text PDFBudding hydromedusae have high reproductive rates due to asexual reproduction and can occur in high population densities along the coasts, specifically in tidal pools. In laboratory experiments, we investigated the effects of population density on the survival and reproductive strategies of a single clone of . We found that sexual reproduction occurs with the highest rate at medium population densities.
View Article and Find Full Text PDFThe role of extrinsic mortality in shaping life histories is poorly understood. However, substantial evidence suggests that extrinsic mortality interacts with density-dependence in crucial ways. We develop a model combining Evolutionarily Stable Strategies with a projection matrix that allows resource allocation to growth, tissue repairs, and reproduction.
View Article and Find Full Text PDFVariation in lifespans is an intriguing phenomenon, but how metabolic rate influence this variation remains unclear. High aerobic capacity can result in health benefits, but also in increased oxidative damage and accelerated ageing. We tested these contradictory predictions using bank voles (Myodes=Clethrionomys glareolus) from lines selected for high swim-induced aerobic metabolism (A), which had about 50% higher maximum metabolic rate and a higher basal and routine metabolic rates, than those from unselected control lines (C).
View Article and Find Full Text PDFLatitudinal differences in life history traits driven by differences in seasonal time constraints have been widely documented. Yet, latitudinal patterns in (age-specific) mortality rates have been poorly studied. Here, we studied latitudinal differences in pre-adult age-specific mortality patterns in the strictly univoltine damselfly Lestes sponsa.
View Article and Find Full Text PDFSenescence, the increase in mortality and decline in fertility with age after maturity, was thought to be inevitable for all multicellular species capable of repeated breeding. Recent theoretical advances and compilations of data suggest that mortality and fertility trajectories can go up or down, or remain constant with age, but the data are scanty and problematic. Here, we present compelling evidence for constant age-specific death and reproduction rates in Hydra, a basal metazoan, in a set of experiments comprising more than 3.
View Article and Find Full Text PDFUnlike other metazoans, Hydra does not experience the distinctive rise in mortality with age known as senescence, which results from an increasing imbalance between cell damage and cell repair. We propose that the Hydra controls damage accumulation mainly through damage-dependent cell selection and cell sloughing. We examine our hypothesis with a model that combines cellular damage with stem cell renewal, differentiation, and elimination.
View Article and Find Full Text PDFPredation is an important selection pressure which shapes aging patterns in natural populations, and it is also a significant factor in the life history decisions of individuals. Exposure to the perceived threat of size-dependent fish predation has been shown to trigger adaptive responses in animal life history including an increase in early reproductive output. In water fleas, this response to perceived predation risk appears to have a cost, as a lifespan in an environment free of predation cues is 20% longer.
View Article and Find Full Text PDFIn a previous theoretical study we investigated whether adaptive or non-adaptive processes are more important in the evolution of senescence. We built a model that combined both processes and found that mutation accumulation is important only at those ages where mortality has a negligible impact on fitness. This model, however, was limited to haploid organisms.
View Article and Find Full Text PDFIs senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-strings to capture different age-specific mutational patterns. Each pattern represents a genotype and for each genotype we find the life history strategy that maximizes fitness.
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