Publications by authors named "Maciej Dabala"
Introduction: Cyclosporin A (CsA) treats moderate to severe psoriasis vulgaris. Psoriasis is a chronic inflammatory disease in which hyperproliferation of keratinocytes occurs. One of the most relevant signaling cascades in the development of psoriasis is the mitogen-activated protein kinase (MAPK) signaling pathway.
View Article and Find Full Text PDFThe purpose of this study was to evaluate the relationship between human papillomavirus (HPV16/18), Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV) infections and the occurrence of ovarian cancer in 48 women, of whom 36 underwent surgery and chemotherapy (group A), 12 in whom surgery was sufficient (group B), and 60 with endometroid endometrial cancer stage G1-G3 (group C), compared to patients in whom the uterus and its appendages were removed for nononcological reasons (control group). The detection of HPV, EBV, and HCMV in tumor tissue and normal tissue was performed using the real-time polymerase chain reaction (RT-PCR) technique. A statistically significantly higher risk of endometrial cancer was noted in patients infected only with HCMV (OR > 1; < 0.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of adalimumab and cyclosporine A on histamine-related gene expression in human keratinocyte cells (HaCaT) stimulated by bacterial lipopolysaccharide (LPS).
- Treatment with LPS was followed by adalimumab or cyclosporine A application, and analyses included RNA extraction and various assays to assess gene regulation.
- Results showed that certain microRNAs related to histamine receptor regulation were downregulated in response to treatments, but additional research is needed to clarify the mechanisms involved in modulating the histaminergic system in psoriasis.
Article Synopsis
- Increased phosphorylated ERK and p38 MAPK levels in psoriatic skin suggest disrupted DUSP expression, prompting this study on DUSP mRNA and miRNA changes in keratinocyte cells exposed to lipopolysaccharide A (LPS).
- The study found significant expression changes, particularly in DUSP2 and DUSP5 after treatment with adalimumab, and identified specific miRNAs that may regulate these DUSPs' expression levels.
- The findings indicate DUSP2 and DUSP5 could serve as valuable molecular markers for diagnosing and monitoring psoriasis treatment, with several specific miRNAs influencing their expression patterns.