Publications by authors named "Machulina N"

Unlabelled: The aim of the research is implementation, approbation and clinical efficiency estimation of treatment schemes of dental caries in children with different dental caries activity.

Materials And Methods: The study included 239 children aged 3 to 15 years (mean age 7.1±1.

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The studies conducted in 27 patients with disseminated suppurative peritonitis and multiorgan failure made it possible to optimize the basic technical parameters of hemofiltration. It has been shown that the volume of replacement of 20-25 1 with postdilution is the optimal. To prevent hemodynamic reactions during hemofiltration, hemodynamic monitoring using impedance plethysmography should be conducted and the speed of the procedure should be changed with the appearance of preclinical signs of chill.

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Hemofiltration (HF) potentials are presented in complex treatment of 12 patients with disseminated suppurative peritonitis in the phase of polyorgan failure with signs of adult respiratory distress syndrome (ARDS). It has been shown that HF reduces the amount of extravascular fluid in the lungs, increases right-to-left pulmonary shunt, eliminates mediators causing higher permeability of pulmonary vessels, and other medium-molecular toxins. Death was recorded in 6 out of 12 patients.

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The influence of the cascade filtration exchange plasmapheresis on the central and organ haemodynamics was studied in 15 patients in the terminal phase of diffuse purulent peritonitis. The procedure was found to be followed by the activation of the cardio-vascular system function if it was initially depressed and by its weakening in cases of excessive strain. The worse functional state of haemodynamics 1 day after plasmapheresis is the earliest symptom of progressing endotoxemia and is though to be an indication for redetoxication.

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Among 115 patients with gastroduodenal hemorrhage 60 received nonoperative treatment, 30 of them underwent enteral correction with a monomer electrolyte solution. Emergency operation was carried out on 55 patients, 35 of them were subjected to enteral correction in the postoperative period. Enteral administration of the monomer electrolyte solution in the early posthemorrhagic and postoperative periods promoted filling up of the blood circulation volume and its components and stabilization of the values of central hemodynamics.

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Feasibility of measuring functional reserve of the myocardium under functional loads simulated by extracorporeal circulation was tried in 36 patients with diffuse purulent peritonitis on filtration detoxication. Altogether 49 sessions of hemofiltration and filtration exchange plasmapheresis were performed controlled by tetrapolar rheography. It is demonstrated that persistent decline of systolic and cardiac output, an increase of central blood volume and occurrence of a pathological impedance wave in response to pre- and postload on the myocardium during extracorporeal detoxication may serve an indication of a subclinical myocardial failure.

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Central, cerebral, pulmonary and peripheral hemodynamics has been studied using impedance plethysmography in 36 terminally ill patients with pyogenic generalized peritonitis. It has been shown that direct dependence of changes in the cardiac output on its cerebral fraction, as well as impedance findings of brain and lung hydration may be considered as prognostically unfavourable. The onset of hypoperfusion of the vital organs which accompanies peripheral vasodilation and decreased hemodynamic activity is associated with unfavourable vital prognosis.

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