Publications by authors named "Machts H"
Article Synopsis
- The study compared various fibrates (like gemfibrozil and fenofibrate) with newly synthesized glycinate and glycinate-methylester derivatives to evaluate their interaction with the cytochrome P450 (CYP) system in rat liver.
- Results showed that the glycinate derivatives generally had a more pronounced effect on CYP-mediated reactions compared to their parent compounds, while clofibrate and its derivatives exhibited the least activity.
- Overall, the derivatives displayed slightly better antioxidant properties than their parent drugs, but no significant advantages in terms of CYP interactions or therapeutic benefits were concluded.
An open problem of the lipid lowering agent ciprofibrate (rac-2-[4-(2,2-dichlorocyclopropyl)-phenoxy]-2-methylpropanoic acid, CAS 52214-84-3) is its metabolism concerning the conjugation with amino acids and glucuronic acid. It could be solved by syntheses of the needed reference compounds--unknown up to now--and administration of ciprofibrate to volunteers and rats. Unexpectedly the conjugation compounds with amino acids are stable in vitro and in metabolism.
View Article and Find Full Text PDFChlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4.
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