Publications by authors named "Machiko Shimmura"
Article Synopsis
- Diabetic retinopathy (DR) is a major cause of vision loss linked to diabetes, prompting a study on the protective effects of pemafibrate in a type 2 diabetes rat model.
- The study involved administering pemafibrate to a group of obese diabetic rats while monitoring their retinal function and health through various examinations, including electroretinography.
- Results indicated that pemafibrate reduced triglycerides and increased good cholesterol, showing improved retinal thickness and larger AQP4-positive areas, suggesting it may help protect against DR.
Objective: The Spontaneously Diabetic Torii (SDT) fatty rat, established by introducing the allele (obesity gene) of the Zucker fatty rat into the SDT rat genome, is a new model of obese type 2 diabetes. We studied the pathologic features of diabetic retinopathy (DR) in this animal.
Methods: The eyes of SDT fatty, SDT (controls), and Sprague Dawley (SD) rats (normal controls) were enucleated at 8, 16, 24, 32, and 40 weeks of age ( = 5-6 for each rat type at each age).
We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diabetes, and 4-micron sections were cut for conventional histopathologic studies.
View Article and Find Full Text PDFPurpose: To clarify the relationship between variations in posterior vitreous detachments (PVDs) and visual prognoses in idiopathic epiretinal membranes (ERMs).
Methods: In this retrospective, observational, and consecutive case series, we observed variations in PVDs in 37 patients (mean age, 65.7±11.
Purpose: To evaluate the effect of ranirestat, a new aldose reductase inhibitor (ARI), on diabetic retinopathy (DR) in Spontaneously Diabetic Torii (SDT) rats.
Methods: The animals were divided into six groups, normal Sprague-Dawley rats (n = 8), untreated SDT rats (n = 9), ranirestat-treated SDT rats (0.1, 1.
The concept of transplantation of corneal parts is to replace only diseased tissues, while leaving healthy host tissues intact. Advantages of the new surgical approaches include fast recovery, resistance to trauma, and less postoperative complications. Despite the theoretical benefits, however, only few data are available in terms of the pros and cons of the new surgical methods.
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