Effects of saikosaponins on hepatic damage induced by halothane and hypoxia in phenobarbital-pretreated rats.

The effects of saikosaponins-a.-b,-b,-c, and-d on hepatic damage induced by halothane and hypoxia were investigated in the rat. Inhalation of halothane under a hypoxic condition significantly increased serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in rats pretreated with phenobarbital compared with rats pretreated without phenobarbital.