Publications by authors named "Macey Henderson"
Unlabelled: The framework currently used for living kidney donor selection is based on estimation of acceptable donor risk, under the premise that benefits are only experienced by the recipient. However, some interdependent donors might experience tangible benefits from donation that cannot be considered in the current framework (ie, benefits experienced directly by the donor that improve their daily life, well-being, or livelihood).
Methods: We conducted semistructured interviews with 56 living kidney donors regarding benefits experienced from donation.
Article Synopsis
- Predialysis nephrology care is linked to better survival rates for patients with end-stage kidney disease, highlighting its importance before starting dialysis.
- The study analyzed data from over 1 million US adults who started dialysis from 2005 to 2015, focusing on racial and ethnic disparities in receiving predialysis care.
- Results showed that racial minorities, particularly Black and Hispanic adults, received significantly less predialysis nephrology care compared to White adults, with minimal improvement in these disparities over time.
Article Synopsis
- - The demand for Vascular Composite Allotransplantation (VCA) donations is expected to rise, highlighting the need for improved public awareness about this treatment option to aid informed decision-making regarding organ donation.
- - A study analyzed 1314 different public education materials from various organizations related to VCA, revealing that subjects like upper extremity and facial transplants were frequently covered, but significant gaps existed regarding information on patient populations that could benefit from VCA and authorization requirements for organ donation.
- - The findings indicate that current educational resources are insufficient, suggesting a need for more comprehensive materials to effectively prepare the public for VCA donations and better inform potential donors about transplant options.
Article Synopsis
- * Only 18 out of the 85 programs surveyed had written protocols for evaluating ILKDs, with barriers such as visa issues and healthcare access being common reasons for not completing evaluations.
- * Evaluating ILKDs requires significantly more staff time compared to domestic candidates, and while some programs report successful follow-up with donors, the process remains resource-intensive and poses variable outcomes.
Article Synopsis
- Caring for dialysis patients places a significant burden on their spouses or partners (referred to as caregiver-partners), who often consider becoming living kidney donors for their loved ones (patient-partners).
- A survey of 99 caregiver-partners revealed that while they experienced increased stress and caregiver burden during dialysis, they reported improvements in various aspects of their lives after their patient-partner received a kidney transplant.
- The findings suggest that the well-being of caregiver-partners should be factored into evaluations of potential kidney donors since their quality of life can significantly improve post-transplant.
Article Synopsis
- Psychosocial factors like depression, anxiety, and social support are significant predictors of medication adherence and graft survival in organ transplant recipients, including those receiving vascularized composite allotransplantation.
- A study surveyed upper extremity transplant patients to evaluate various psychosocial aspects and found that most recipients were considered adherent to their medication; however, some exhibited signs of non-adherence and mild psychological issues.
- The findings suggest that factors such as high social support and conscientiousness are linked to better medication adherence, while anxiety and PTSD may hinder it, indicating a need for further investigation into these psychosocial influences.
Article Synopsis
- * The increase in donations was particularly notable among unrelated and paired white donors, showing substantial growth across different age groups.
- * The research indicates a need to encourage kidney donation among unrelated black individuals, as their donation rates lag behind other groups despite some growth in specific demographics.
Article Synopsis
- * Results showed that a majority were open to receiving both living (87%) and deceased (84%) HIV+ donor organs, despite some concerns about risks like HIV superinfection.
- * Acceptance of HIV+ organs was higher among candidates from centers with prior HIV D+/R+ transplants, suggesting that experience may boost confidence in the safety of these transplants.
Simple (Bosniak I) renal cysts are considered acceptable in living kidney donor selection in terms of cancer risk. However, they tend to increase in number and size over time and might compromise renal function in donors. To clarify their implications for long-term renal function, we characterized the prevalence of renal cysts in 454 individuals who donated at our center from 2000 to 2007.
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- End-stage kidney disease patients in the US can have international donors—friends or family members who are not US citizens but want to donate a kidney.
- In 2017, a team of experts from various fields came together to address the challenges and gaps in evaluating and caring for these international donors.
- They created recommendations covering areas like donor evaluation, logistics, and postdonation care, aiming to help programs manage the unique complexities of international living donations more effectively.
Article Synopsis
- Living kidney donation increases the long-term risk of developing end-stage renal disease (ESRD), and identifying early markers can help in risk assessment and counseling for donors.
- This study analyzed data from a national registry of living kidney donors in the U.S. to explore the link between kidney function in the first six months after donation and the risk of ESRD later on.
- Results indicated that lower kidney function (measured by eGFR) six months postdonation significantly correlates with a higher risk of ESRD; for every 10 mL/min decline in eGFR, the risk of ESRD increased by 28%.
Rationale & Objective: Risk factors for kidney failure are the basis of live kidney donor candidate evaluation. We quantified risk for end-stage kidney disease (ESKD) by the biological relationship of the donor to the recipient, a risk factor that is not addressed by current clinical practice guidelines.
Study Design: Retrospective cohort study.
The landscape of vascularized composite allograft donation in the United States.
Curr Opin Organ Transplant
December 2019
Article Synopsis
- Vascularized composite allograft (VCA) donation and transplantation is becoming a viable option for patients with severe injuries, showing positive effects on their quality of life.
- Donor selection for VCA transplants is critical, focusing on minimizing risks to recipients; the donor pool in the U.S. mirrors the demographic characteristics of transplant candidates.
- Public support for VCA donation is increasing, although it remains lower compared to support for solid organ transplants, indicating a need for further awareness.
Background: Limited data are available regarding clinical implications of lower renal function after living kidney donation. We examined a novel integrated database to study associations between postdonation estimated glomerular filtration rate (eGFR) and use of antihypertensive medication (AHM) treatment after living kidney donation.
Methods: Study data were assembled by linking national U.
Although minimized by expert evaluation, operative technique, and postoperative care, the extremely low risk of perioperative mortality following living kidney or liver donation will never be eliminated. Furthermore, anticipation of poor donor outcome may simultaneously be a source of anxiety for physicians and programs and also be a circumstance for which they are unprepared. We conducted a national survey of US transplant surgeons to understand experiences with and systemic preparedness for the event of a living donor death.
View Article and Find Full Text PDFFactors related to travel for transplantation were examined using data from the Scientific Registry for Transplant Recipients. Candidates who traveled abroad for a kidney transplant had higher odds of being male, Asian or Hispanic, college-educated, employed, privately insured, and a non-U.S.
View Article and Find Full Text PDFWe examined a novel linkage of national US donor registry data with records from a pharmacy claims warehouse (2007-2016) to examine associations (adjusted hazard ratio, aHR ) of post-donation fills of antidiabetic medications (ADM, insulin or non-insulin agents) with body mass index (BMI) at donation and other demographic and clinical factors. In 28 515 living kidney donors (LKDs), incidence of ADM use at 9 years rose in a graded manner with higher baseline BMI: underweight, 0.9%; normal weight, 2.
View Article and Find Full Text PDFBackground And Objectives: Hypertension in older kidney donor candidates is viewed as safe. However, hypertension guidelines have evolved and long-term outcomes have not been explored. We sought to quantify the 15-year risk of ESKD and mortality in older donors (≥50 years old) with versus those without hypertension.
View Article and Find Full Text PDFBackground: United States transplant centers are required to report follow-up data for living kidney donors for 2 years post-donation. However, living kidney donor (LKD) follow-up is often incomplete. Mobile health (mHealth) technologies could ease data collection burden but have not yet been explored in this context.
View Article and Find Full Text PDFPurpose Of Review: HIV-infected (HIV+) and hepatitis C virus-infected (HCV+) individuals with end-stage renal disease (ESRD) have decreased access to kidney transplantation. With new opportunities provided by the HIV Organ Policy Equity (HOPE) Act and direct-acting antivirals (DAAs) for HCV, we explore the potential risks and benefits of living donor kidney transplantation from HIV+ or HCV+ donors, from the perspective of both donor health and recipient outcomes.
Recent Findings: The HOPE Act permits organ donation from both deceased and living HIV+ persons to HIV+ recipients; however, there is only clinical experience with HIV+ deceased donors to date.