Publications by authors named "Macejane Ferreira Souza"
Correction for Ferreira et al., "Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax".
Letícia Tiburcio Ferreira Juliana Rodrigues Gustavo Capatti Cassiano Tatyana Almeida Tavella Kaira Cristina Peralis Tomaz Macejane Ferreira Souza
Antimicrob Agents Chemother
October 2020
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax.
Letícia Tiburcio Ferreira Juliana Rodrigues Gustavo Capatti Cassiano Tatyana Almeida Tavella Kaira Cristina Peralis Tomaz Macejane Ferreira Souza
Antimicrob Agents Chemother
August 2020
Article Synopsis
- - Widespread resistance to current antimalarial drugs has sparked the urgent need for new effective treatments, leading researchers to explore drug repositioning as a cost-effective strategy.
- - A computer-assisted drug repositioning approach identified seven promising drug candidates, with epirubicin being highlighted for further testing due to its strong effectiveness against both drug-sensitive and resistant malaria strains.
- - Experimental validation revealed that epirubicin not only kills malaria parasites but also blocks their transmission, and further studies aim to understand its mechanism of action, suggesting it could be optimized for use in malaria treatment.