Implications of recently derived thermodynamic data and specific ionic interaction theory parameters for (Mg/Ca)UO(CO) complexes on the predominance of the Mg-Ca-UO-OH-CO systems, and application to natural and legacy-mine waters.

The formation of alkaline earth(II)triscarbonatouranyl(VI) (AeUO(CO)) species that have been evidenced both in laboratory and in-field studies, is important from slightly acidic pH up to near degraded cementitious in carbonated waters. They are also showing distinctive luminescence properties with a hypsochromic shift relative to UO. The conditions of pH, activities of alkaline earth(II) free ions (mostly Mg and Ca) and carbonate ions (HCO) can be predicted from the thermodynamic functions and constants.

Radiolysis effect on Eu(III)-superplasticiser interactions in artificial cement and squeezed cement pore waters.

In the framework of the French deep geological repository for radioactive waste, cement-based materials are envisaged to immobilize radionuclides and/or provide protection from radiation to the environment. Superplasticisers (SPs) are added to these materials to increase their workability. SPs will undergo degradation by coupled radiolytic and hydrolytic effects in the pore solution leading to the formation of potentially complexing degradation products.

Drug-Disease Interaction and Time-Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients.

Isatuximab, a monoclonal antibody (mAb) of immunoglobulin G (IgG) isotype, specifically targets the cluster of differentiation 38 antigen overexpressed in malignant plasma cells. Isatuximab is used to treat multiple myeloma (MM), characterized by the excessive production of abnormal "myeloma proteins" (M-proteins) that may interact with therapeutic IgG mAb on the neonatal Fc receptor (FcRn)-mediated recycling pathway. The clinical pharmacology profile of isatuximab was investigated by population pharmacokinetics (PKs) modeling in 476 patients with MM who received 1-20 mg/kg isatuximab either as single agent or in combination with pomalidomide-dexamethasone in 4 clinical trials.

Multifractal Scalings Across the Many-Body Localization Transition.

In contrast with Anderson localization where a genuine localization is observed in real space, the many-body localization (MBL) problem is much less understood in Hilbert space, the support of the eigenstates. In this Letter, using exact diagonalization techniques we address the ergodicity properties in the underlying N-dimensional complex networks spanned by various computational bases for up to L=24 spin-1/2 particles (i.e.

How mobile is tritiated water through unsaturated cement-based materials? New insights from two complementary approaches.

This work presents two complementary approaches (for low and high desaturation) to study tritiated water (HTO) diffusion through unsaturated cement-based materials. The first approach was based on through-diffusion experiments where suction was controlled by osmosis. In the second approach, diffusion experiments were performed in humidity chambers controlled by under-saturated saline solutions.

A luminescence line-narrowing spectroscopic study of the uranium(VI) interaction with cementitious materials and titanium dioxide.

Non-selective luminescence spectroscopy and luminescence line-narrowing spectroscopy were used to study the retention of UO2(2+) on titanium dioxide (TiO2), synthetic calcium silicate hydrate (C-S-H) phases and hardened cement paste (HCP). Non-selective luminescence spectra showed strong inhomogeneous line broadening resulting from a strongly disordered UO2(2+) bonding environment. This problem was largely overcome by using luminescence line-narrowing spectroscopy.

Birth of kids after artificial insemination with sex-sorted, frozen-thawed goat spermatozoa.

Successful sex-sorting of goat spermatozoa and subsequent birth of pre-sexed kids have yet to be reported. As such, a series of experiments were conducted to develop protocols for sperm-sorting (using a modified flow cytometer, MoFlo SX(®) ) and cryopreservation of goat spermatozoa. Saanen goat spermatozoa (n = 2 males) were (i) collected into Salamon's or Tris catch media post-sorting and (ii) frozen in Tris-citrate-glucose media supplemented with 5, 10 or 20% egg yolk in (iii) 0.

Determination of uranium(VI) sorbed species in calcium silicate hydrate phases: a laser-induced luminescence spectroscopy and batch sorption study.

Batch sorption experiments and time-resolved luminescence spectroscopy investigations were carried out to study the U(VI) speciation in calcium silicate hydrates for varying chemical conditions representing both fresh and altered cementitious environments. U(VI) uptake was found to be fast and sorption distribution ratios (R(d) values) were very high indicating strong uptake by the C-S-H phases. In addition a strong dependence of pH and solid composition (Ca:Si mol ratio) was observed.

Measurement and modeling of the surface potential evolution of hydrated cement pastes as a function of degradation.

Hydrated cement pastes (HCP) have a high affinity with a lot of (radio)toxic products and can be used as waste confining materials. In cementitious media, elements are removed from solution via (co)precipitation reactions or via sorption/diffusion mechanisms as surface complexation equilibria. In this study, to improve the knowledge of the surface charge evolution vs the degradation of the HCP particles, two cements have been studied: CEM-I (ordinary Portland cement, OPC) and CEM-V (blast furnace slag and fly ash added to OPC).

Unraveling substantia nigra sequential gene expression in a progressive MPTP-lesioned macaque model of Parkinson's disease.

Taking advantage of a progressive nonhuman primate model mimicking Parkinson's disease (PD) evolution, we monitored transcriptional fluctuations in the substantia nigra using Affymetrix microarrays in control (normal), saline-treated (normal), 6 days-treated (asymptomatic with 20% cell loss), 12 days-treated (asymptomatic with 40% cell loss) and 25 days-treated animals (fully parkinsonian with 85% cell loss). Two statistical methods were used to ascertain the regulation and real-time quantitative PCR was used to confirm their regulation. Surprisingly, the number of deregulated transcripts is limited at all time points and five clusters exhibiting different profiles were defined using a hierarchical clustering algorithm.

Insulin Receptor Processing and Lipid Composition of Erythrocyte Membrane in Patients with Hyperlipidemia.

The aim of this study was to determine whether the common forms of dyslipidemia could affect either the lipid composition or insulin receptor processing (down-regulation) of erythrocytes. The study included 22 patients with type IIa hypercholesterolemia, 15 patients with type IV hypertriglyceridemia and 12 patients with type IIb hyperlipidemia. Ten normolipidemic subjects were used as controls.