Publications by authors named "Macarena Lopez-Mayorga"
Article Synopsis
- The study explores how transposable elements, originally mobile genetic sequences, became functional genes in the genomes of humans and mice, particularly focusing on a gene cluster called Bex/Tceal.
- This gene cluster is important in various signaling pathways and has been linked to neurological disorders like autism and schizophrenia, showing distinct expression patterns in affected individuals.
- The research provides insights into the evolutionary process that turned non-functional genetic sequences into vital parts of the mammalian genome, highlighting the role of Bex3 in brain function and potential involvement in human neurological challenges.
The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of muscle regeneration due to its high cell turnover. The resident satellite cells (the bona fide muscle stem cells) remain poorly characterized. Here we analyzed PC satellite cells with regard to developmental origin and purported function.
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- Research shows that how DNA is organized in 3D shapes inside cells affects how genes work, but we still don't completely understand it.
- Scientists studied the Six homeobox genes, which are important for development, and found that these genes are organized in a specific 3D structure that's been around since before many animal types appeared.
- By changing parts of this structure in zebrafish, they learned that this 3D organization helps genes behave differently even when they're close together, and certain patterns in DNA are common across many animals!