Effect of different neuromuscular training modalities on postural stability in healthy recreation people: a randomized controlled trial.

This study aimed to determine the effects of dynamic neuromuscular stabilization (DNS), whole-body vibration (WBV), and a combination of DNS and WBV (MIX) training modalities on postural stability (PS) in healthy recreation participants. The 179 participants (age 24.02 ± 2.

Effects of linear and change of direction high-intensity interval training on physical performance of elite female soccer players.

The aim of this study was to determine the effects of linear and change of direction high-intensity interval training (HIIT) on physical performance in elite female soccer players. Thirty elite female soccer players (age: 19.6 ± 4.

Efficient high-precision homology-directed repair-dependent genome editing by HDRobust.

Homology-directed repair (HDR), a method for repair of DNA double-stranded breaks can be leveraged for the precise introduction of mutations supplied by synthetic DNA donors, but remains limited by low efficiency and off-target effects. In this study, we report HDRobust, a high-precision method that, via the combined transient inhibition of nonhomologous end joining and microhomology-mediated end joining, resulted in the induction of point mutations by HDR in up to 93% (median 60%, s.e.

Corrigendum: Effect of neuromuscular training program on quality of life after COVID-19 lockdown among young healthy participants: A randomized controlled trial.

[This corrects the article DOI: 10.3389/fpsyg.2022.

Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development.

Since the ancestors of modern humans separated from those of Neanderthals, around 100 amino acid substitutions spread to essentially all modern humans. The biological significance of these changes is largely unknown. Here, we examine all six such amino acid substitutions in three proteins known to have key roles in kinetochore function and chromosome segregation and to be highly expressed in the stem cells of the developing neocortex.

Comment on "Reintroduction of the archaic variant of in cortical organoids alters neurodevelopment".

Trujillo . (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, providing another plausible explanation for the effects observed.

The effects of daily physical activity intervention on physical fitness in preschool children.

The study aimed to determine the effects of 6 months daily physical activity on physical fitness in preschool children. A total of 72 children (36 boys) and 92 children (47 boys) composed the experimental (EG) and control group (CG), respectively. We used the PREFIT battery access physical fitness.

Intensity-Modified Recreational Volleyball Training Improves Health Markers and Physical Fitness in 25-55-Year-Old Men.

The present study is aimed at determining the effects of intensity-modified recreational volleyball training on health markers and physical fitness in healthy middle-aged men. Thirty-four healthy untrained men aged 25-55 years were randomized to either a modified recreational volleyball group (MRV, = 17) or a recreational volleyball group (RV, = 17). Both groups performed volleyball training twice a week over 12 weeks, with participants in MRV playing a modified game with higher intensity due to shorter breaks between rallies.

Speed, Change of Direction Speed and Reactive Agility in Adolescent Soccer Players: Age Related Differences.

There are a plethora of studies investigating agility in soccer; however, studies have rarely presented the reaction time in differentiating age groups in adolescent soccer players. We investigated age differences in reactive agility, speed, and change of direction speed (CODs), in a group of highly trained adolescent soccer players. A total of 75 adolescent male soccer players (aged 14-19 years) were recruited.

Body Composition in Elite Soccer Players from Youth to Senior Squad.

There is a strong relationship between body composition and performance in male soccer players. This study aimed to display an optimal body height and weight, and body composition profile of male soccer players for four competitive age groups. This cross-sectional study included four groups: U-15 ( = 152), U-17 ( = 154), U-19 ( = 61), and seniors ( = 27).

Reduced purine biosynthesis in humans after their divergence from Neandertals.

We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccinate lyase, which catalyzes two reactions in purine synthesis, occur at lower concentrations in humans. This enzyme carries an amino acid substitution that is present in all humans today but absent in Neandertals.

Effect of Integrated Neuromuscular Exercise in Physical Education Class on Health-Related Fitness in Female Children.

Integrated neuromuscular training (INT) showed benefits for improving fundamental movement skills (FMS). However, the INT health-related fitness (HRF) effects are lacking. The current study aimed to determine the effects of INT implemented during physical education (PE) in a primary school in the Republic of Serbia on HRF in female children.

[Custom-Made 3D Printed Titanium Acetabular Component: Advantages and Limits of Use].

The authors report on three cases in which a custom-made 3D printed titanium acetabular component of total hip arthroplasty was used to manage an advanced acetabular bone defect with pelvic discontinuity. The implant surface structure impeded long-term bone integration. Nonetheless, the stable bridging of the acetabular defect resulted in full integration of impacted bone allografts at the base of the implant.

Relationship between Motor Competence, Physical Fitness, and Academic Achievement in Young School-Aged Children.

Children in schools are facing many academic challenges. Moreover, there is constant pressure on children and parents to maximize academic achievement. We aimed to determine the relationship between motor competence, physical fitness, and academic achievement in young school-aged children.

A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2.

SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fast screening method based on direct RT-qPCR to detect SARS-CoV-2 in single or pooled gargle lavages ("mouthwashes"). This method detects individuals with large viral loads (Ct≤29) and we use it to test all staff at a nursing home daily over a period of three weeks in order to reduce the risk that the infection penetrates the facility.

Short-Term Core Strengthening Program Improves Functional Movement Score in Untrained College Students.

Functional movement is an important part of developing athletes' but also untrained individuals' performance. Its monitoring also proved useful in identifying functional limitations and asymmetries, and also in determining the intervention effects. The quasi-experimental pre-test post-test study investigated the effects of core stability training program on the Functional Movement Screen (FMS) score in untrained students after six weeks.

Squamous cell carcinoma of the colon - a case report.

Background: Primary squamous cell carcinomas (SCC) of the colon are extremely rare and occur predominantly in the fifth decade of life, with a slight prevalence in men. The most common anatomical sites are the rectum and the proximal colon. Clinical signs and common dia-gnostic methods cannot clearly distinguish SCC from adenocarcinoma.

Anthropometric and Motor Competence Classifiers of Swimming Ability in Preschool Children-A Pilot Study.

Swimming is a form of physical activity and a life-saving skill. However, only a few studies have identified swimming ability classifiers in preschool children. This pilot cross-sectional study aimed to find anthropometric (AM) and motor competence (MC) predictors of swimming ability in preschool children, by building classifiers of swimming ability group (SAG) membership.

Evaluation of Gross Motor Coordination and Physical Fitness in Children: Comparison between Soccer and Multisport Activities.

The early detection and continuous monitoring of children's motor competence levels and physical fitness is very important. The purpose of this study was to determine the differences in motor coordination of children enrolled in soccer and multisport activities. The participants of this study included 147 boys and girls (mean age 7.

Complete Response to Chemotherapy in Metastatic Pancreatic Carcinoma Associated with Double Heterozygous Germline Mutation in BRCA2 and CHEK2 Genes - a Case Report.

Background: Metastatic pancreatic carcinoma is an aggressive disease with adverse prognosis. Despite slight advances in chemotherapy, complete remission of the disease is extremely rare.

Case: In this article we present a case of a patient with initially metastatic pancreatic adenocarcinoma, associated with double heterozygous germline mutation in BRCA2 and CHEK2 genes, with the description of clinical, radiological and histomorphological characteristics of the disease as well as the dia-gnostic and therapeutic procedure.

Nine Months of a Structured Multisport Program Improve Physical Fitness in Preschool Children: A Quasi-Experimental Study.

Research in preschool children that investigates the impact of different exercise interventions on physical fitness is limited. This pre-post study was aimed at determining if participation in a nine-month structured multisport program (MSG; n = 38) could enhance physical fitness components compared to a formal exercise program (control group (CG); n = 36) among preschool children. Physical fitness was assessed using standardized tests (the standing long jump, sit and reach, 20 m sprint, sit-ups for 30 s, bent-arm hang, medicine ball throw (MBT), grip strength, 4 × 10 m shuttle run, and 20 m shuttle run tests).

Eight months of school-based soccer improves physical fitness and reduces aggression in high-school children.

School-based programmes have shown promising results in the reduction of aggressive behaviour, but the effectiveness of physical activity modalities among adolescents remains to be determined. The aim of this study was to determine the effects of a school-based soccer programme on physical fitness and aggression in adolescent students. One hundred and five high school students were randomized to a small-sided soccer training group (SG) or a control group (CG).