Syndrome of growth resistance, obesity, and intellectual impairment with precocious puberty.

A syndrome of growth resistance, obesity, and intellectual impairment with precocious puberty is described. Two girls presenting with many of the manifestations of the Prader-Willi syndrome, including growth resistance, obesity, and intellectual impairment, also exhibited precocious sexual maturation. It is suggested that this syndrome represents a hypothalamic disturbance closely related to the Prader-Willi syndrome and should be considered one of its variants.

The extraction of polymeric collagen from biopsies of human skin.

1. Medium sized biopsies (100 mm2) of human skin from 14 subjects yielded sufficient polymeric collagen for depolymerisation and ultrastructural investigations. 2.

'Little leopard' syndrome. Description of 3 cases and review of 24.

Three cases of the `Little Leopard' syndrome are described; its features are short stature, lentigines, electrocardiographic and ocular defects, pulmonary infundibular stenosis, abnormal genitalia, mental retardation, and deafness. The published material is reviewed, and the cardiac and electrocardiographic abnormalities are described in detail.