A cross-sectional comparison of the association between self-reported sources of stress and psychological distress among Canadian undergraduate and graduate students.

: This study aimed to (1) descriptively compare stressors experienced by postsecondary students at the undergraduate versus graduate levels of study, and (2) evaluate the relationship between stressors and psychological distress, controlling for the effects of level of study. : Undergraduate ( = 3774) and graduate ( = 889) students across 15 Canadian universities who completed the Post-Secondary Student Index electronic survey in October of 2020. : Mean severity score for stressors were compared between level of study.

Evaluation and Application of the Work-Related Asthma Screening Questionnaire-Long Version (WRASQ(L)).

Background: The Work-related Asthma (WRA) Screening Questionnaire-Long Version (WRASQ(L)) is a screening questionnaire that could improve the recognition of WRA.

Objective: To conduct a definitive evaluation of the WRASQ(L) to justify its implementation in clinical settings.

Methods: Employed adults aged 18 to 75 years with asthma confirmed by objective measures and the ability to take time off work were eligible.

Telepharmacy for outpatients with cancer: An implementation evaluation of videoconsults compared to telephone consults using the CFIR 2.0.

Background: Medication history telepharmacy consults are conducted prior to patients commencing their systemic anti-cancer therapy. At the study institution, this has historically been carried out as an unscheduled telephone consult. However, due to challenges with telephone consults, a scheduled videoconsult model was established.

An Experimental Test of Jealousy's Evolved Function: Imagined Partner Infidelity Induces Jealousy, Which Predicts Positive Attitude Towards Mate Retention.

Jealousy may have evolved to motivate adaptive compensatory behavior in response to threats to a valued relationship. This suggests that jealousy follows a temporal sequence: A perceived relational threat induces state feelings of jealousy which in turn motivates compensatory behavior, such as mate retention effort. Yet to date, tests of this mediation model have been limited to cross-sectional data.

Asymmetry in linear measurements and cross-sectional geometry in the humerus during ontogeny.

Objectives: Adult upper limb asymmetry is used to reconstruct behavior. However, the developmental trajectory of asymmetry in bone length, cross-sectional geometry (CSG), and joint dimensions is poorly understood. This study examines the development trajectory of humeral asymmetry and if asymmetry in bone length, joint size, and CSG develop in concert.

Calcium signaling mediates proliferation of the precursor cells that give rise to the ciliated left-right organizer in the zebrafish embryo.

Several of our internal organs, including heart, lungs, stomach, and spleen, develop asymmetrically along the left-right (LR) body axis. Errors in establishing LR asymmetry, or laterality, of internal organs during early embryonic development can result in birth defects. In several vertebrates-including humans, mice, frogs, and fish-cilia play a central role in establishing organ laterality.

Community-based screening enhances hepatitis B virus linkage to care among West African migrants in Spain.

Background: Chronic infection with HBV is responsible for >50% of all hepatocellular cancer cases globally and disproportionately affects sub-Saharan African (sSA) countries. Migration from these countries to Europe has increased substantially in recent years, posing unique challenges to health systems. The aim of this study was to carry out a community-based intervention to increase HBV screening, vaccination, and linkage to care among sSA migrants in Catalonia, Spain.

Women's Romantic Jealousy Predicts Risky Appearance Enhancement Effort.

Human appearance enhancement effort has recently been considered from an evolutionary perspective as an adaptive and sexually dimorphic strategy for effective female intrasexual and intersexual competition. Most writing and research on the topic to date has focused on appearance enhancement as a means of mate attraction, with relatively less research examining its role in mate retention. The present study considered whether romantic jealousy, as a negative emotion experienced in response to perceived threat to a desired relationship, predicts costly and/or risky appearance enhancement independent of the closely related emotion of envy.

Gains in relative cortical area during growth and their relationship to nutrition, body size, and physical activity.

Objectives: In studies of growth in the past, low percentage of cortical area (%CA) is commonly attributed to poor general health, due to factors including poor nutrition, low socioeconomic status, or other physiological stressors. What constitutes low relative cortical dimensions has not been established across a diverse range of human skeletal samples. This study examines %CA in a large immature skeletal sample to establish typical variation in humans with consideration of both body mass and subsistence strategy.

A scoping review of factors associated with antimicrobial-resistant species infections in humans.

Human infection with antimicrobial-resistant species is an important public health concern due to the potentially increased severity of illness and risk of death. Our objective was to synthesise the knowledge of factors associated with human infections with antimicrobial-resistant strains of This scoping review followed systematic methods, including a protocol developed Comprehensive literature searches were developed in consultation with a research librarian and performed in five primary and three grey literature databases. Criteria for inclusion were analytical and English-language publications investigating human infections with an antimicrobial-resistant (macrolides, tetracyclines, fluoroquinolones, and/or quinolones) that reported factors potentially linked with the infection.

Lifestyle coaching is feasible in fatigued brain tumor patients: A phase I/feasibility, multi-center, mixed-methods randomized controlled trial.

Background: There are no effective treatments for brain tumor-related fatigue. We studied the feasibility of two novel lifestyle coaching interventions in fatigued brain tumor patients.

Methods: This phase I/feasibility multi-center RCT recruited patients with a clinically stable primary brain tumor and significant fatigue (mean Brief Fatigue Inventory [BFI] score ≥ 4/10).

Integrating User Preferences for Asthma Tools and Clinical Guidelines Into Primary Care Electronic Medical Records: Mixed Methods Study.

Background: Asthma is a chronic respiratory disease that poses a substantial burden on individuals and the health care system. Despite published national guidelines for the diagnosis and management of asthma, considerable care gaps exist. Suboptimal adherence to asthma diagnosis and management guidelines contributes to poor patient outcomes.

Primary care asthma surveillance: a review of knowledge translation tools and strategies for quality improvement.

Background: Viable knowledge translation (KT) strategies are increasingly sought to improve asthma diagnosis, particularly in primary care. Despite this understanding, practical KT tools to support primary care practitioners are not widely available. Electronic medical records (EMRs) offer an opportunity to optimize the diagnosis and surveillance of chronic diseases such as asthma, and support quality improvement initiatives that increase adherence to guideline-recommended care.

Urban Biomimicry for Flood Mitigation Using an Ecosystem Service Assessment Tool in Central Wellington, New Zealand.

Many cities are vulnerable to flooding due to their high proportion of impervious surfaces and lack of vegetated land cover. This vulnerability will often be exacerbated by changing rainfall and storm patterns due to climate change. Using the principles of urban biomimicry, this study aims to show an ecosystem service-based approach to designing an urban green infrastructure network for stormwater management in densely built areas that more closely emulates natural hydrology processes.

Characterisation of burden of illness measures associated with human (Fluoro)quinolone-resistant spp. infections - a scoping review.

spp. are one of the most common causes of bacterial gastroenteritis in Canada and worldwide. Fluoroquinolones are often used to treat complicated human campylobacteriosis and strains of spp.

Patterns of enteric infections in a population-wide cohort study of sequelae, British Columbia, Canada.

We assessed patterns of enteric infections caused by 14 pathogens, in a longitudinal cohort study of sequelae in British Columbia (BC) Canada, 2005-2014. Our population cohort of 5.8 million individuals was followed for an average of 7.

An evaluation of telephone versus videoconference consults for pre-treatment medication history taking by cancer pharmacists.

Introduction: The primary aim was to compare the successful completion rates of pre-treatment medication history consults conducted by pharmacists with patients either via an unscheduled telephone consult (current standard care) or a scheduled videoconference consult model. Secondary aims were to examine pharmacist perceptions of the telephone and videoconference consults and explore patient (+/- support person) perceptions of videoconference consults.

Method: Completion data were collected and compared for the two modalities.

QSAR models reveal new EPAC-selective allosteric modulators.

Exchange proteins directly activated by cAMP (EPAC) are guanine nucleotide exchange factors for the small GTPases, Rap1 and Rap2. They regulate several physiological functions and mitigation of their activity has been suggested as a possible treatment for multiple diseases such as cardiomyopathy, diabetes, chronic pain, and cancer. Several EPAC-specific modulators have been developed, however studies that quantify their structure-activity relationships are still lacking.

Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse.

The objective of this study was to determine the diagnostic ability of serum amyloid A (SAA) and fibrinogen for early detection of surgical site infection (SSI) after equine internal fixation. Horses undergoing internal fixation for fracture, arthrodesis, or osteotomy with internal fixation for limb deformity were included in the study. SAA and fibrinogen were measured on blood samples preoperatively and on days 1, 3, 5, 7, 10, and 14 postoperatively.

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.

Gram-negative bacteria are intrinsically resistant to a plethora of antibiotics that effectively inhibit the growth of Gram-positive bacteria. The intrinsic resistance of Gram-negative bacteria to classes of antibiotics, including rifamycins, aminocoumarins, macrolides, glycopeptides, and oxazolidinones, has largely been attributed to their lack of accumulation within cells due to poor permeability across the outer membrane, susceptibility to efflux pumps, or a combination of these factors. Due to the difficulty in discovering antibiotics that can bypass these barriers, finding targets and compounds that increase the activity of these ineffective antibiotics against Gram-negative bacteria has the potential to expand the antibiotic spectrum.

Implementation of a Work-Related Asthma Screening Questionnaire in Clinical Settings: Multimethods Study.

Background: A work-related asthma (WRA) screening questionnaire is currently being validated for implementation in clinical settings. To minimize barriers to integrating tools into clinical practice, a discussion of strategies for the implementation of the questionnaire has begun.

Objective: This study aimed to understand the benefits, feasibility, barriers, and limitations of implementing the Work-related Asthma Screening Questionnaire-Long version (WRASQ[L]) and asthma e-tools in clinical settings and propose dissemination and implementation strategies for the WRASQ(L).