Publications by authors named "MacKenzie A P Wilke"
Article Synopsis
- Cisplatin-induced ototoxicity (CIO) leads to irreversible hearing loss and is influenced by both clinical factors and genetic variants, with polygenic scores (PGS) emerging as a potential predictive tool for identifying individuals at risk for CIO.
- * Researchers developed two PGSs based on large-scale hearing loss GWAS data and RNA sequencing from murine inner ear cells affected by cisplatin, revealing that one PGS significantly outperformed the other in predicting CIO risk.
- * This study presents the first PGS for CIO and suggests that combining genetic data with biological insights can enhance pharmacogenomic research, ultimately aiding in personalized treatment plans for patients undergoing cisplatin therapy.
Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction. The application of these scores to pharmacogenomics provides new opportunities to improve the prediction of treatment outcomes. To gain insight into this area of research, we conducted a systematic review and accompanying analysis.
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