Publications by authors named "Maboubeh Varmazyad"
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) affects about 30% of the global population, driven by a mix of genetic, lifestyle, and environmental factors, complicating treatment and clinical trial design.*
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- The study utilized a liver acinus microphysiology system (LAMPS) made from patient-derived cells to explore the effects of the PNPLA3 rs738409 genetic variant on MASLD progression, replicating various metabolic conditions.*
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- Results showed that the PNPLA3 GG variant led to increased liver fat, immune activation, and pro-fibrotic factor secretion compared to wild type cells, providing insights for future treatments like resmetirom.*
