Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH).

Purpose: Some pesticides may increase the risk of certain lymphoid malignancies, but few studies have examined Hodgkin lymphoma (HL). In this exploratory study, we examined associations between agricultural use of 22 individual active ingredients and 13 chemical groups and HL incidence.

Methods: We used data from three agricultural cohorts participating in the AGRICOH consortium: the French Agriculture and Cancer Cohort (2005-2009), Cancer in the Norwegian Agricultural Population (1993-2011), and the US Agricultural Health Study (1993-2011).

Residential proximity to crops and agricultural pesticide use and cause-specific mortality: A prospective census-based cohort study in the Netherlands.

Background: There is continued concern about residential proximity to agricultural pesticide use and possible adverse health effects. Studies on this subject have been scarce with inconsistent results. We explored associations between residential proximity to specific crops, pesticide use and cause-specific mortality in a prospective census-based cohort study in The Netherlands.

Animal farming and the risk of lymphohaematopoietic cancers: a meta-analysis of three cohort studies within the AGRICOH consortium.

Objective: Animal farming entails a variety of potential exposures, including infectious agents, endotoxins and pesticides, which may play a role in the aetiology of lymphohaematopoietic cancers (LHCs). The aim of this study was to assess whether farming specific animal species is associated with the risk of overall LHC or its subtypes.

Methods: Data from three prospective cohort studies in the USA, France and Norway which are part of the Agricultural Cohort consortium and which collected information about animal farming and cancer were used.

Parkinson's disease and long-term exposure to outdoor air pollution: A matched case-control study in the Netherlands.

Background: There is some evidence to suggest an association between ambient air pollution and development of Parkinson's disease (PD). However, the small number of studies published to date has reported inconsistent findings.

Objectives: To assess the association between long-term exposure to ambient air pollution constituents and the development of PD.

Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium.

Background: Pesticides are commonly used in agriculture, and previous studies endorsed the need to further investigate the possible association between their use and risk of lymphoid malignancies in agricultural workers.

Methods: We investigated the relationship of ever use of 14 selected pesticide chemical groups and 33 individual active chemical ingredients with non-Hodgkin lymphoid malignancies (NHL) overall or major subtypes, in a pooled analysis of three large agricultural worker cohorts. Pesticide use was derived from self-reported history of crops cultivated combined with crop-exposure matrices (France and Norway) or self-reported lifetime use of active ingredients (USA).

Associations of residential exposure to agricultural pesticides with asthma prevalence in adolescence: The PIAMA birth cohort.

Background: It has been suggested that children who are exposed to agricultural pesticides have an increased risk of asthma, but evidence for associations betweeen residential pesticide exposure and childhood asthma is inconsistent.

Objectives: To investigate the associations of residential pesticide exposure with the prevalence of asthma and related symptoms within a Dutch birth cohort study.

Methods: In this cross-sectional analysis, we included participants of the PIAMA birth cohort study with data on residential pesticide exposure and asthma from parent-completed questionnaires at age 14, collected in 2012 (N = 1473).

Environmental exposure to pesticides and the risk of Parkinson's disease in the Netherlands.

Background: Exposure to pesticides has been linked to Parkinson's disease (PD), although associations between specific pesticides and PD have not been well studied. Residents of rural areas can be exposed through environmental drift and volatilization of agricultural pesticides.

Objectives: Our aim was to investigate the association between lifetime environmental exposure to individual pesticides and the risk of PD, in a national case-control study.

Proximity to agricultural fields as proxy for environmental exposure to pesticides among children: The PIAMA birth cohort.

Background: Agricultural pesticides are frequently used for crop protection. Residents living in close proximity to treated fields may be exposed to these pesticides. There is some indication that children living near agricultural fields have an increased risk of developing asthma and decreased lung function.

Assessment of residential environmental exposure to pesticides from agricultural fields in the Netherlands.

We developed a spatio-temporal model for the Netherlands to estimate environmental exposure to individual agricultural pesticides at the residential address for application in a national case-control study on Parkinson's disease (PD). Data on agricultural land use and pesticide use were combined to estimate environmental exposure to pesticides for the period 1961 onwards. Distance categories of 0-50 m, >50-100 m, >100-500 m and >500-1000 m around residences were considered.

Assessment of occupational exposure to pesticides in a pooled analysis of agricultural cohorts within the AGRICOH consortium.

Background: This paper describes methods developed to assess occupational exposure to pesticide active ingredients and chemical groups, harmonised across cohort studies included in the first AGRICOH pooling project, focused on the risk of lymph-haematological malignancies.

Methods: Three prospective agricultural cohort studies were included: US Agricultural Health Study (AHS), French Agriculture and Cancer Study (AGRICAN) and Cancer in the Norwegian Agricultural Population (CNAP). Self-reported pesticide use was collected in AHS.

Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort.

Objectives: We investigated the association between six occupational exposures (ie, pesticides, solvents, metals, diesel motor emissions (DME), extremely low frequency magnetic fields (ELF-MF) and electric shocks) and Parkinson's disease (PD) mortality in a large population-based prospective cohort study.

Methods: The Netherlands Cohort Study on diet and cancer enrolled 58,279 men and 62,573 women aged 55-69 years in 1986. Participants were followed up for cause-specific mortality over 17.

Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands.

Objectives: Previous research has indicated that occupational exposure to pesticides and possibly airborne endotoxin may increase the risk of developing Parkinson disease (PD). We studied the associations of PD with occupational exposure to pesticides, specifically to the functional subclasses insecticides, herbicides and fungicides, and to airborne endotoxin. In addition we evaluated specific pesticides (active ingredients) previously associated with PD.

Expert assessment of historical crop specific pesticide use in the Netherlands.

Objectives: Retrospective assessment of environmental pesticide exposure is challenging. Exposure measurements or information on crop-specific pesticide use are often lacking historically. We applied expert assessment to reconstruct historical pesticide use patterns in the Netherlands, and evaluated reliability and accuracy of this procedure.

Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results.

Background: Previous systematic reviews have indicated that pesticide exposure is possibly associated with Parkinson disease (PD). However, considerable heterogeneity has been observed in study results.

Objective: We aimed at providing an update of the literature published on PD and exposure to pesticides by performing a systematic review and meta-analysis.