Safety and efficacy of procedural sedation with propofol in a country with a young emergency medicine training program.

Objectives: To evaluate the safety and effectiveness of procedural sedation with propofol by newly trained Dutch emergency physicians.

Methods: A prospective observational cohort study of patients in emergency department undergoing procedural sedation at two teaching hospitals. Primary outcomes were serious adverse events, sedation events, and efficacy.

Evaluation of the necessity of clinical observation of high-energy trauma patients without significant injury after standardized emergency room stabilization.

Background: Patients involved in a high-energy trauma (HET) are usually admitted for clinical observation, even when no significant injury is found after standard care in the emergency room (ER). The necessity of this observation period is not evidence based. The goal of this study was to identify patients who revealed an initially undiagnosed injury during the observation period.

Conscious sedation for EUS of the esophagus and stomach: a double-blind, randomized, controlled trial comparing midazolam with placebo.

Background: Patients undergoing EUS usually receive intravenously administered sedative medication. A double-blind, prospective, randomized trial was conducted to compare midazolam with a placebo for EUS of the esophagus and stomach and to assess patient tolerance and endoscopic feasibility.

Methods: A total of 111 patients were randomized to receive midazolam or a placebo.